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别名 甲磺美嗪, Lu-1631, Amezinium metilsulfate, Amezinium (methylsulfate)
Amezinium methylsulfate (Lu-1631) 具有多种机制,包括刺激 α 和 β-1 受体以及抑制去甲肾上腺素和酪胺的摄取。

Amezinium methylsulfate (Lu-1631) 具有多种机制,包括刺激 α 和 β-1 受体以及抑制去甲肾上腺素和酪胺的摄取。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 mg | ¥ 298 | In Stock | |
| 100 mg | ¥ 418 | In Stock | |
| 1 mL x 10 mM (in DMSO) | ¥ 460 | In Stock |
Amezinium methylsulfate 相关产品
| 产品描述 | Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake. |
| 体内活性 | 在5名多系统萎缩症患者中,使用每日15 mg的amezinium metilsulfate(一种肾上腺素能化合物)治疗姿势性低血压6个月,与治疗前相比,治疗后排尿后残余量明显增加(治疗前113 ml,治疗后178 ml,变化率为37%)[1]。amezinium明显提高了FTBF的减少比率(安慰剂75.9%;amezinium 85.1%;midodrine 78.1%]。amezinium显著降低了产生半最大静脉收缩的去甲肾上腺素的输注速率(安慰剂40.6 ng/min;amezinium 21.0 ng/min)[2]。 |
| 别名 | 甲磺美嗪, Lu-1631, Amezinium metilsulfate, Amezinium (methylsulfate) |
| 分子量 | 313.33 |
| 分子式 | C12H15N3O5S |
| CAS No. | 30578-37-1 |
| Smiles | COS([O-])(=O)=O.COc1cc(N)cn[n+]1-c1ccccc1 |
| 密度 | no data available |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 50 mg/mL (159.58 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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DMSO
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