规格

价格

库存

数量

1 mg

¥ 283

现货

2 mg

¥ 395

现货

5 mg

¥ 647

现货

10 mg

¥ 913

现货

25 mg

¥ 1,770

现货

50 mg

¥ 3,230

现货

100 mg

¥ 4,780

现货

500 mg

¥ 9,870

现货

1 mL x 10 mM (in DMSO)

¥ 647

现货

生物活性

产品描述	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
靶点活性	EP300:0.051 μM, CBP:0.03 μM, BRD4 BD1:11 μM
体外活性	CPI-637 inhibits MYC expression in AMO-1 cells (EC50=0.60 μM)[1].
激酶实验	Ki Determination: Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis.
细胞实验	AMO-1 cells (DSMZ) were plated at 20,000 cells/well in 96-well plates in Iscove's Modified Dulbecco's Medium supplemented with 10% fetal calf serum. Cells were treated for 6 h with a dose titration of CPI-637 starting from a 5 μM top concentration. After 6 h, cells were lysed and processed for QuantiGene Plex expression analysis and data were collected on a MAGPIX multiplex Luminex instrument.(Only for Reference)
别名	CPI 637

化学信息

分子量	386.45
分子式	C₂₂H₂₂N₆O
CAS No.	1884712-47-3
Smiles	C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
密度	1.38 g/cm3 (Predicted)