规格

价格

库存

数量

1 mg

¥ 145

现货

5 mg

¥ 335

现货

10 mg

¥ 551

现货

25 mg

¥ 1,100

现货

50 mg

¥ 1,770

现货

100 mg

¥ 2,590

现货

1 mL x 10 mM (in DMSO)

¥ 359

现货

生物活性

产品描述	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
靶点活性	μ-Calpain:260 nM, m-Calpain:5.33 μM
体内活性	PD151746可使HMEC-1细胞中氧化型低密度脂蛋白诱导的细胞毒性降低。PD151746有效减弱SY5Y细胞中鱼毒素诱导的SLLVY-AMC水解作用。
激酶实验	Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit.

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 44 mg/mL (185.46 mM), Sonication is recommended.

Ethanol: 44 mg/mL (185.46 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.43 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol