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alpha-1 antitrypsin fragment

产品编号 TP2217 CAS TP2217

Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms.

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alpha-1 antitrypsin fragment Chemical Structure

alpha-1 antitrypsin fragment, CAS TP2217

规格	价格/CNY	货期
1 mg	￥ 483	待询
5 mg	￥ 1,383	待询
10 mg	￥ 2,283	待询
25 mg	￥ 3,183	待询

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生物活性

化学信息

存储 & 溶解度

产品描述	Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms.
体外活性	A1AT is a major inhibitor of human serine proteases in serum, is produced mainly by the liver, but also by extrahepatic cells, including neutrophils and certain cancer cells. AAT is an acute-phase protein and its concentration rises up to 3–4-fold above normal during acute inflammation. Several types of cancer, including non-small cell lung adenocarcinoma, have been associated with increased serum levels of AAT [1][2][3].
体内活性	Moreover, not only the native, the inhibitory form of AAT but also conformationally modified, non-inhibitory forms are suggested to play a role in modulating tumor growth and invasiveness. For example, Kataoka and co-workers have shown that the C-terminal fragment of AAT can enhance the growth and invasiveness of human pancreas adenocarcinoma cells, in vivo [5].

分子量	1804.01
分子式	C79H130N22O26
CAS No.	TP2217

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: > 45.1 mg/mL, Heating is recommended.

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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