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Succimer

Name: Succimer
Brand: TargetMol
SKU: T2552
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.8%

货号 T2552Cas号 304-55-2

别名 内消旋-2,3-二巯基丁二酸, 二巯基丁二酸, meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acid

Succimer (Dimercaptosuccinic acid) 是一种螯合剂，广泛用于铅中毒的研究。

Succimer

一键复制产品信息

很棒

纯度: 99.8%

货号 T2552 别名 内消旋-2,3-二巯基丁二酸, 二巯基丁二酸, meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acidCas号 304-55-2

Succimer (Dimercaptosuccinic acid) 是一种螯合剂，广泛用于铅中毒的研究。

规格	价格	库存
200 mg	¥ 108	现货
500 mg	¥ 163	现货
1 g	¥ 226	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.8%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Succimer AI Summary

Succimer exhibits noteworthy bioactivity and pharmacological properties across several domains. It shows significant inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with inhibition percentages ranging from 97.72% to 98.97% at a 20 µM concentration and varying IC50 values reported (6.743 µM and 0.0836 µM for different substrates). Additionally, it demonstrates antiviral activity by reducing cytotoxicity in Caco-2 and VERO-6 cells in response to SARS-CoV-2 at a concentration of 10 µM. The compound also inhibits Escherichia coli chaperone proteins GroEL and GroES, impacting protein folding activities. On the other hand, Succimer is associated with moderate liver toxicity, indicated by elevated liver enzymes such as ALT, AST, alkaline phosphatase, SGOT, SGPT, LDH, and GGT. However, it does not cause acute liver toxicity or specific types of hepatotoxicity like cytolytic or cholestatic injury, nor does it lead to severe liver conditions like hepatitis, cirrhosis, or tumors. Clinical trials indicate a moderate prevalence (56.7%) of hepatotoxicity. In terms of its effects on human HDAC6, Succimer shows modest inhibition with percentages of 28.73% and 2.09% in enzymatic assays using different substrates. It does not exhibit significant bioactivity against an array of human and rat receptors and enzymes, with AC50 values consistently above 30000.0 nM. Additionally, it has been documented to have a severity class index of 2.0 for drug-induced liver injury in humans. Overall, Succimer's profile suggests potential as an antiviral agent against SARS-CoV-2, albeit with considerations for its moderate hepatotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Succimer (Dimercaptosuccinic acid) is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.
别名	内消旋-2,3-二巯基丁二酸, 二巯基丁二酸, meso-2,3-dimercaptosuccinic acid, DMSA, Dimercaptosuccinic acid

化学信息

分子量	182.22
分子式	C₄H₆O₄S₂
CAS No.	304-55-2
Smiles	[C@H]([C@H](C(O)=O)S)(C(O)=O)S
密度	1.617 g/cm3

储存&溶解度

存储

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (274.39 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.98 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4879 mL	27.4394 mL	54.8787 mL	274.3936 mL
5 mM	1.0976 mL	5.4879 mL	10.9757 mL	54.8787 mL
10 mM	0.5488 mL	2.7439 mL	5.4879 mL	27.4394 mL
20 mM	0.2744 mL	1.3720 mL	2.7439 mL	13.7197 mL
50 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4879 mL
100 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7439 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Succimer Mercury Lead Inhibitor inhibit

Succimer

Succimer

Succimer 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词