2-Benzylsuccinic acid

Name: 2-Benzylsuccinic acid
Brand: TargetMol
SKU: T8093
Price: 195 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.01%

货号 T8093Cas号 884-33-3

别名 DL-Benzylsuccinic acid, 2-苄基丁二酸

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) 是羧肽酶 A (CPA) 抑制剂。

2-Benzylsuccinic acid

一键复制产品信息

很棒

纯度: 99.01%

货号 T8093 别名 DL-Benzylsuccinic acid, 2-苄基丁二酸Cas号 884-33-3

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) 是羧肽酶 A (CPA) 抑制剂。

规格	价格	库存
200 mg	¥ 275	现货
500 mg	¥ 435	现货
1 g	¥ 627	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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产品介绍

2-Benzylsuccinic acid AI Summary

2-Benzylsuccinic acid is a multifunctional inhibitor with significant bioactivities against various enzymes, cancer cell lines, and viral proteases. It inhibits Carboxypeptidase A (CPA) strongly with a Ki value of 450.0 nM and an IC50 of 400.0 nM, and moderately inhibits Carboxypeptidase B (CPB) with an IC50 of 1600.0 nM. It shows no significant inhibition of Carboxypeptidase N (CPN) or Carboxypeptidase M (CPM) with IC50 values above 50000.0 nM. Additionally, 2-Benzylsuccinic acid inhibits bovine CPA1 with a Ki of 500.0 nM, while showing weaker inhibition of human recombinant CPB (Ki of 10000.0 nM) and corn earworm recombinant CPB (Ki of 11900.0 nM). In oncology, 2-Benzylsuccinic acid demonstrates potent growth inhibition of various human tumor cell lines, including breast, renal, lung, prostate, central nervous system, melanoma, ovarian, leukemia, and colon cells, as shown by its GI50 values in the NCI human tumor cell line growth inhibition assay. For antiviral activity, it inhibits the SARS-CoV-2 3CL-Pro protease by 24.9% at a concentration of 20µM in a FRET assay. Moreover, it exhibits inhibitory effects against SARS-CoV-2 with a 0.2% inhibition rate of its cytotoxic effects on VERO-6 cells at a concentration of 10uM after 48 hours. Lastly, in a clot lysis assay using human plasma, the compound achieved maximum acceleration of lysis at concentrations greater than 50.0 μM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is a bacterial xenobiotic metabolite.
别名	DL-Benzylsuccinic acid, 2-苄基丁二酸

化学信息

分子量	208.21
分子式	C₁₁H₁₂O₄
CAS No.	884-33-3
Smiles	OC(=O)CC(CC1=CC=CC=C1)C(O)=O
密度	1.290 g/cm3 (Predicted)

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 41 mg/mL (196.92 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (19.21 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL	240.1422 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL	48.0284 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL	24.0142 mL
20 mM	0.2401 mL	1.2007 mL	2.4014 mL	12.0071 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
100 mM	0.0480 mL	0.2401 mL	0.4803 mL	2.4014 mL