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D-Cycloserine
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很棒纯度: 99.01%
货号 T1589Cas号 68-41-7
别名 RO-1-9213, D-环丝氨酸
D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
其他形式的 “D-Cycloserine”:
D-Cycloserine
一键复制产品信息 很棒纯度: 99.01%
货号 T1589 别名 RO-1-9213, D-环丝氨酸Cas号 68-41-7
D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 169 | 现货 | |
| 50 mg | ¥ 228 | 现货 | |
| 100 mg | ¥ 317 | 现货 | |
| 500 mg | ¥ 578 | 现货 | |
| 1 g | ¥ 842 | 现货 |
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产品介绍
D-Cycloserine AI Summary
D-Cycloserine exhibits a broad spectrum of bioactivities, with notable antimicrobial, antimycobacterial, and antiviral properties. It shows strong antibacterial activity against various bacterial strains including Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from as low as 0.25 μg/mL to 128.0 μg/mL. Specifically, it is highly effective against Escherichia coli ATCC 9637 with MIC values of 0.25 μg/mL and 0.5 μg/mL. The compound also displays significant inhibitory activity against Mycobacterium tuberculosis strains, including drug-resistant isolates, with MIC50 values around 5.0 μg/mL and MIC90 values of 24,500 nM.
Furthermore, D-Cycloserine demonstrates potent antiviral activity, notably against SARS-CoV-2, showing significant inhibition of virus-induced cytotoxicity in VERO-6 cells at various tested concentrations. Additionally, it exhibits moderate efficacy in inhibiting the NMDA receptor with IC50 and EC50 values in the nanomolar range. Despite some hepatotoxicity indications, the compound shows promise in medical applications, particularly for treating infections caused by antibiotic-resistant bacteria and tuberculosis strains, as well as certain viral infections like COVID-19..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents. |
| 别名 | RO-1-9213, D-环丝氨酸 |
| 分子量 | 102.09 |
| 分子式 | C3H6N2O2 |
| CAS No. | 68-41-7 |
| Smiles | N[C@H]1C(=O)NOC1 |
| 密度 | 1.278 g/cm3 |
| 存储 | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| 溶解度信息 | H2O: 6.66 mg/mL (65.24 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
| 体内实验配方 | Saline: 10.1 mg/mL (98.93 mM), Solution. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
H2O
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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