规格

价格

库存

数量

1 mg

¥ 413

现货

5 mg

¥ 892

现货

10 mg

¥ 1,230

现货

25 mg

¥ 2,080

现货

50 mg

¥ 3,130

现货

100 mg

¥ 4,480

现货

200 mg

¥ 6,280

现货

生物活性

产品描述	ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
体外活性	Clostridium histolyticum 胶原酶 (ChC) 的活性受到芦荟凝胶的剂量依赖性抑制，活性导向的分级得到了一个富含酚类和Aloin的活性组分。Aloin被证明能够可逆地且非竞争性地与 ChC 结合并抑制其活性。芦荟凝胶和Aloin也是刺激性粒细胞基质金属蛋白酶 (MMPs) 的有效抑制剂[1]。
体内活性	Aloin 有效地通过缓解 p38 和 ERK 途径来抑制唾液 IL-1β 诱导的 IL-8 产生。因此，aloin 可以是调节口腔炎症性疾病的一个好候选物[2]。
动物实验	Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1].
别名	芦荟素,葡糖基蒽酮,芦荟大黄素甙, 芦荟苷

化学信息

分子量	418.398
分子式	C₂₁H₂₂O₉
CAS No.	8015-61-0
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc12
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50.00 mg/mL (119.50 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (4.78 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9503 mL	23.9007 mL	119.5034 mL
5 mM	0.4780 mL	2.3901 mL	4.7801 mL	23.9007 mL
10 mM	0.2390 mL	1.1950 mL	2.3901 mL	11.9503 mL
20 mM	0.1195 mL	0.5975 mL	1.1950 mL	5.9752 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1950 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Aloin(mixture of A&B)

Aloin(mixture of A&B)

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Aloin(mixture of A&B)

Aloin(mixture of A&B)