规格

价格

库存

数量

1 mg

¥ 413

现货

5 mg

¥ 892

现货

10 mg

¥ 1,230

现货

25 mg

¥ 2,080

现货

50 mg

¥ 3,130

现货

100 mg

¥ 4,480

现货

200 mg

¥ 6,280

现货

生物活性

产品描述	ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
体外活性	Clostridium histolyticum 胶原酶 (ChC) 的活性受到芦荟凝胶的剂量依赖性抑制，活性导向的分级得到了一个富含酚类和Aloin的活性组分。Aloin被证明能够可逆地且非竞争性地与 ChC 结合并抑制其活性。芦荟凝胶和Aloin也是刺激性粒细胞基质金属蛋白酶 (MMPs) 的有效抑制剂[1]。
体内活性	Aloin 有效地通过缓解 p38 和 ERK 途径来抑制唾液 IL-1β 诱导的 IL-8 产生。因此，aloin 可以是调节口腔炎症性疾病的一个好候选物[2]。
动物实验	Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1].
别名	芦荟素,葡糖基蒽酮,芦荟大黄素甙, 芦荟苷

化学信息

分子量	418.398
分子式	C₂₁H₂₂O₉
CAS No.	8015-61-0
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc12
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50.00 mg/mL (119.50 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (4.78 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO