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- 3111个植物来源天然产物的独特集合；
- 可用于高通量筛选和高内涵筛选；
- 处于临床前研究或临床期实验阶段，是颇具研究潜力的天然产物集合；
- 包含青蒿素，人参皂苷等热门的天然产物；
- 结构多样，药效显著，可渗透细胞；
- 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
- NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
植物来源化合物库
Selected Plant-Sourced Compound Library
很棒自然界创造了几乎无穷无尽的分子实体，为药物研发特别是新型药效团的发现创造了无限资源。在全球范围内，天然产物自古以来一直都是传统治疗的支柱。植物作为药物治疗疾病具有悠久的历史，植物来源的化合物具有更好的耐受性和可接受性。迄今为止，已对35,000-70,000种植物进行了药用筛选。半合成纯药物阿司匹林，是基于从白柳中分离出的天然产品水杨苷，由拜耳于1899年推出。此后陆续分离出了多种早期药物，如洋地黄毒苷、奎宁和毛果芸香碱等，其中一些仍在使用中，以及其他一些近期出现的植物衍生化合物，这些化合物经过开发并已作为药物销售，其中包括:来自短叶红豆杉的紫杉醇，用于肺部、卵巢癌和乳腺癌；青蒿素来自中国传统植物青蒿，用于对抗多药耐药性疟疾；水飞蓟素从水飞蓟种子中提取，用于治疗肝脏疾病。 TargetMol 植物来源化合物库精选3111 个植物来源天然产物的独特集合，具有良好的成药潜力，可用于天然产物来源的化合物筛选和新药研发。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
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植物来源化合物库规格
- 1 mg
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品描述
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
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文献引用
1.Zhang J W, Wang H, Liu J, et al. Generation of A Stable GFP-reporter Zika Virus System for High-throughput Screening of Zika Virus Inhibitors. Virologica Sinica. 2021 Jun;36(3):476-4892.Yi D, Li Q, Wang H, et al. Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral Glycoprotein. Acta Pharmaceutica Sinica B. 20223.Khan I, Li S, Tao L, et al.Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1.Nature Communications.2024, 15(1): 162.4.Ma Y, Song Y, Wang J, et al.Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening.Future Medicinal Chemistry.2024 (0).
化合物库组成
Endogenous Metabolite
Apoptosis
Antibacterial
NF-κB
Autophagy
Antioxidant
Antifungal
COX
Reactive Oxygen Species
Parasite
Cytochromes P450
TNF
Influenza Virus
NO Synthase
IL Receptor
AChR
Cholinesterase (ChE)
Anti-infection
HIV Protease
ERK
GABA Receptor
p38 MAPK
Akt
PPAR
Antibiotic
Caspase
Calcium Channel
STAT
Tyrosinase
AMPK
Antifection
DNA/RNA Synthesis
Nrf2
ROS
JNK
MMP
Lipoxygenase
Bcl-2 Family
PI3K
Virus Protease
NOS
TRP/TRPV Channel
Immunology/Inflammation related
5-HT Receptor
Microtubule Associated
ATPase
Dehydrogenase
Estrogen Receptor/ERR
PKC
Antiviral
Ferroptosis
PDE
P-gp
Beta Amyloid
Potassium Channel
HSV
Topoisomerase
Glucosidase
Prostaglandin Receptor
Sodium Channel
HBV
Estrogen/progestogen Receptor
PARP
Wnt/beta-catenin
MAO
EGFR
Adrenergic Receptor
Interleukin
SARS-CoV
TLR
Mitophagy
JAK
HDAC
Adenosine Receptor
Phosphatase
Mitochondrial Metabolism
Dopamine Receptor
Drug Metabolite
TGF-beta/Smad
MAPK
HIF/HIF Prolyl-Hydroxylase
Reductase
CDK
transporter
Phospholipase
Platelet aggregation
HCV Protease
BACE
RAAS
VEGFR
mTOR
Sirtuin
p53
Monoamine Oxidase
LDL
Fatty Acid Synthase
Androgen Receptor
IκB/IKK
Cannabinoid Receptor
NOD
PKA
UGT
PAFR
HIF
Histamine Receptor
iGluR
NMDAR
Opioid Receptor
Xanthine Oxidase
GluR
Beta-Secretase
HSP
GPR
MEK
Proteasome
Chloride channel
Carbonic Anhydrase
GSK-3
Nucleoside Antimetabolite/Analog
Amylase
Gamma-secretase
FAAH
cAMP
Epigenetic Reader Domain
DNA
Indoleamine 2,3-Dioxygenase (IDO)
Free radical scavengers
Reverse Transcriptase
FAK
HER
Transferase
ADC Cytotoxin
Integrin
NADPH
MRP
Serine Protease
Cell Cycle Arrest
Aryl Hydrocarbon Receptor
IAP
PTEN
IGF-1R
CaMK
ATP Citrate Lyase
PGE Synthase
Aromatase
PDK
Syk
NOD-like Receptor (NLR)
Proton pump
Src
LTR
c-Myc
Tyrosine Kinases
Serine/threonin kinase
Liver X Receptor
FXR
E1/E2/E3 Enzyme
Bcr-Abl
ABC Transporter
Monoamine Transporter
Hedgehog/Smoothened
CCR
CXCR
Telomerase
SGLT
Acyltransferase
Histone Acetyltransferase
GST
FGFR
HMG-CoA Reductase
S6 Kinase
MicroRNA
ROR
c-Met/HGFR
Histone Demethylase
Lipase
gp120/CD4
OCT
Pim
Serotonin Transporter
Cysteine Protease
Leukotriene Receptor
RANKL/RANK
Adiponectin Receptor
P2X Receptor
Smo
DPP-4
Bombesin Receptor
PDGFR
Aurora Kinase
Lipid
OAT
Aminopeptidase
hCE
PAI-1
Pyroptosis
RSV
Casein Kinase
ATM/ATR
Retinoid Receptor
PLK
NADPH-oxidase
DNA Methyltransferase
IRAK
Ras
Thrombin
Imidazoline Receptor
S1P Receptor
Vitamin
Thyroid hormone receptor(THR)
Advanced Glycation End Products
Mdm2
Adenylyl Cyclase
Transaminase
NPC1L1
stilbene oxidase
RAR/RXR
CD38
CYP19A1
Histone Methyltransferase
Dynamin
MyD88
Arginase
LPL Receptor
P2Y Receptor
IFNAR
Aconitase
DYRK
PERK
Glutathione Peroxidase
Factor Xa
Progesterone Receptor
CaSR
Glucokinase
Glucocorticoid Receptor
IDO
Prolyl Endopeptidase (PREP)
MTH1
Fas/FasL
Raf
Glucagon Receptor
Phosphorylase
DNA gyrase
PAK
Stearoyl-CoA Desaturase (SCD)
Angiotensin-converting Enzyme (ACE)
Chk
PAD
Thrombopoietin Receptor
Norepinephrine
Survivin
Trk receptor
CPT
Decarboxylase
ALK
Adenosine Deaminase
ATTECs
NMU2R
FLT
ROS Kinase
AhR
PD-1/PD-L1
化合物库信息
| Empty | 99-96-7 | 99-93-4 | 99-86-5 | 99-85-4 | 99-76-3 | 99759-48-5 | 99530-82-2 | 99-50-3 | 99-48-9 | 99365-23-8 | Empty |
| 4-Hydroxybenzoic acid | 4-Hydroxyacetophenone | α-Terpinene | γ-Terpinene | Methyl Paraben | 6-Benzoylheteratisine | Cucurbitacin Q1 | Protocatechuic acid | Carveol | Prosaikogenin G | ||
| Empty | 99353-00-1 | 99-32-1 | 99-24-1 | 99224-12-1 | 99-14-9 | 99-10-5 | 99-06-9 | 98985-24-1 | 989-51-5 | 989-30-0 | Empty |
| Methyl rosmarinate | Chelidonic acid | Methyl gallate | herbacetin-3,8-diglucopyranoside | Tricarballylic acid | 3,5-Dihydroxybenzoic acid | 3-Hydroxybenzoic acid | yibeinoside A | (-)-Epigallocatechin Gallate | 3-Epiursolic acid | ||
| Empty | 989-23-1 | 98891-44-2 | 98891-41-9 | 98619-25-1 | 98-55-5 | 98474-78-3 | 98474-74-9 | 98243-57-3 | 981-15-7 | 97938-31-3 | Empty |
| Deoxylimonin | Pseudolaric acid A-O-β-D-glucopyranoside | Pseudolaric acid B β-D-glucoside | Schisandrone | α-Terpineol | Pseudoginsenoside RT5 | Pseudoginsenoside RT1 | Hupehenine | Ailanthone | Leachianone A | ||
| Empty | 97938-30-2 | 97871-44-8 | 97-67-6 | 97-61-0 | 97-59-6 | 97-54-1 | 97-53-0 | 97465-69-5 | 97-41-6 | 973-67-1 | Empty |
| Sophoraflavanone G | Isotoosendanin | (S)-Malic acid | 2-METHYLVALERIC ACID | Allantoin | Isoeugenol | Eugenol | Hydroxy-β-sanshool | Ethyl chrysanthemate | 5,6,7-TRIMETHOXYFLAVONE | ||
| Empty | 97230-47-2 | 97230-46-1 | 97207-47-1 | 970-74-1 | 970-73-0 | 97005-76-0 | 96990-65-7 | 96990-18-0 | 96574-01-5 | 96553-02-5 | Empty |
| Picfeltarraenin IA | Picfeltarraenin IB | Meisoindigo | (-)-Epigallocatechin | (+)-Gallocatechin | 4'-Methoxyflavanone | 3-Feruloyl-4-caffeoylquinic acid | Momordin Ic | Salvianolic acid A | Gypsogenin-3-O-glucuronide | ||
| Empty | 96400-45-2 | 96382-91-1 | 96382-90-0 | 96-17-3 | 961-29-5 | 96087-21-7 | 95975-55-6 | 959-33-1 | 959-23-9 | 957-66-4 | Empty |
| Luteolin 7-diglucuronide | Neonuezhenide | Oleuropeinic acid | 2-Methylbutyraldehyde | Isoliquiritigenin | Stylopine hydrochloride | Guggulsterone | 4-METHOXYCHALCONE | 4'-Methoxychalcone | Isolinderalactone | ||
| Empty | 95-71-6 | 95480-80-1 | 95258-14-3 | 952068-57-4 | 951-78-0 | 95041-90-0 | 95-01-2 | 94987-08-3 | 94942-49-1 | 948-60-7 | Empty |
| Pyrolin | 5-Hydroxy-7-acetoxy-8-methoxyflavone | Yadanziolide A | Parishin E | 2'-Deoxyuridine | Erianin | 2,4-Dihydroxybenzaldehyde | Gypenoside XLIX | 6-Methoxynaringenin | Pterine-6-carboxylic acid | ||
| Empty | 94805-82-0 | 94-75-7 | 94705-70-1 | 94-62-2 | 94596-28-8 | 94596-27-7 | 945619-74-9 | 94-53-1 | 94492-24-7 | 94487-74-8 | Empty |
| Glycycoumarin | 2,4-D | Gypenoside XLVI | Piperine | Senkyunolide I | Senkyunolide H | OPHIOPOGONIN D | Piperonylic acid | 2'-acetylacteoside | Angelic anhydride |
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