Potassium oxonate is a uricase inhibitor that suppresses the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and is commonly used to establish hyperuricemia models.

Potassium oxonate是S-1的成分之一，S-1是一种含有抗肿瘤化合物5-氟尿嘧啶前药的混合物，它能够抑制5-氟尿嘧啶在大鼠中的胃肠道毒性[1]。含有Potassium oxonate的配方已被用于治疗胃癌、胰腺癌、肺癌、头颈癌及乳腺癌[2]。