LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2].

LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against FaDu tumor xenografts??and human A253 without significant toxicity[1].