Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with the medium [1]. Docebenone at 10-200 μM increases [Ca2+]i concentration-dependently [2].

In monkeys, Docebenone (0.01-10 μM) suppresses the release of SRS-A by 55-97% with a dose-dependently manner. The antigen-induced SRS-A release from these fragments is dose-dependently inhibited by 25-93% of Docebenone (0.01-10 μM) [4]. Docebenone may protect experimental acute necrotizing pancreatitis in rats [3].