Name: Calderasib
Brand: TargetMol
SKU: T86905
Price: 7830 CNY
Availability: InStock
Rating: 5 (10 reviews)

Calderasib

很棒

产品编号 T86905Cas号 2641216-67-1

别名 MK-1084, MK1084

Calderasib (MK-1084) 是一种选择性 KRAS G12C 抑制剂，其 IC50 值为 1.2 nM。Calderasib (MK-1084) 表现出显著的抗癌活性，可单独应用，也可与 PD-1 抑制剂 Pembrolizumab 联合使用，为 KRAS 突变驱动癌症的研究提供了多样化策略。

规格

价格

库存

数量

1 mg

¥ 7,830

In stock

5 mg

¥ 15,800

In stock

10 mg

¥ 21,600

In stock

25 mg

¥ 31,900

In stock

产品介绍

生物活性

产品描述	Calderasib (MK-1084) is a selective KRAS G12C inhibitor with an IC50 value of 1.2 nM . Calderasib (MK-1084) exhibits significant anticancer activity, and it can be employed either as a monotherapy or in combination with the PD-1 inhibitor Pembrolizumab, providing a versatile approach for the investigation of KRAS-mutant driven cancers.
体外活性	Calderasib (MK-1084) (0.01-10 μM, 2 h) 抑制H358细胞中 ERK1/2 的磷酸化，IC50 为 9 nM。[2]
体内活性	Calderasib (MK-1084)（10-30 mg/kg，连续14天）口服给药于小鼠MiaPaCa-2异种移植模型，结果显示Calderasib (MK-1084)显著抑制了肿瘤的生长。[2]
别名	MK-1084, MK1084

化学信息

分子量	637.08
分子式	C₃₂H₃₁ClF₂N₆O₄
CAS No.	2641216-67-1
Smiles	O=C1N2C=3C(C(=N1)N4C(C)CN(C(C=C)=O)C(C)C4)=CC(Cl)=C(N3)C=5C(=C(F)C=CC5F)OCCOC=6C2=C(C(C)C)N=CC6
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 80 mg/mL (125.57 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5697 mL	7.8483 mL	15.6966 mL	78.4831 mL
5 mM	0.3139 mL	1.5697 mL	3.1393 mL	15.6966 mL
10 mM	0.1570 mL	0.7848 mL	1.5697 mL	7.8483 mL
20 mM	0.0785 mL	0.3924 mL	0.7848 mL	3.9242 mL
50 mM	0.0314 mL	0.1570 mL	0.3139 mL	1.5697 mL
100 mM	0.0157 mL	0.0785 mL	0.1570 mL	0.7848 mL

体内实验配液计算器