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Complement factor H/CFH Protein, Human, Recombinant (His)

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SPR兼容缓冲液
货号 TMPK-00790

别名 HUS, HF2, HF1, HF, H factor 1, FHL1, FH, Complement factor H, CFHL3, CFH, ARMS1, ARMD4, AMBP1, AHUS1

Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.

Complement factor H/CFH Protein, Human, Recombinant (His)

Complement factor H/CFH Protein, Human, Recombinant (His)

一键复制产品信息
Rating icon 很棒
SPR兼容缓冲液
货号 TMPK-00790 别名 HUS, HF2, HF1, HF, H factor 1, FHL1, FH, Complement factor H, CFHL3, CFH, ARMS1, ARMD4, AMBP1, AHUS1

Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.

规格价格库存数量
5 μg
¥ 313
现货
10 μg
¥ 498
现货
20 μg
¥ 793
现货
50 μg
¥ 1,580
3日内发货
100 μg
¥ 2,660
现货
200 μg
¥ 4,790
5日内发货
500 μg
¥ 10,600
5日内发货
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选择批次:
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
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产品介绍


生物活性
产品描述
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
生物活性
Immobilized Human Factor H, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Factor H Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA.
研究背景
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
种属
Human
表达系统
HEK293 Cells
标签C-His
蛋白编号P08603-1
蛋白构建Ser860-Arg1231
蛋白纯度
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名HUS, HF2, HF1, HF, H factor 1, FHL1, FH, Complement factor H, CFHL3, CFH, ARMS1, ARMD4, AMBP1, AHUS1
内毒素< 1 EU/μg by the LAL method.
化学信息
分子量42.8 kDa (predicted). Due to glycosylation, the protein migrates to 60-68 kDa based on Tris-Bis PAGE result.
颜色White
物理性状Lyophilized powder
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice.
存储It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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