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SD 0006

Name: SD 0006
Brand: TargetMol
SKU: T7276
Price: 237 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.32%

货号 T7276Cas号 271576-80-8

别名 SD-06, 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑

SD 0006 (SD-06) 是一种选择性的、ATP 竞争性的、口服有效的p38α MAPK 的二芳基吡唑抑制剂，IC50值为 110 nM。它可用于治疗关节炎。

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SD 0006

一键复制产品信息

很棒

纯度: 98.32%

货号 T7276 别名 SD-06, 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑Cas号 271576-80-8

SD 0006 (SD-06) 是一种选择性的、ATP 竞争性的、口服有效的p38α MAPK 的二芳基吡唑抑制剂，IC50值为 110 nM。它可用于治疗关节炎。

规格	价格	库存
1 mg	¥ 237	现货
5 mg	¥ 548	现货
10 mg	¥ 798	现货
25 mg	¥ 1,510	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,400	现货
200 mg	¥ 4,750	现货
1 mL x 10 mM (in DMSO)	¥ 496	现货

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COA HNMR LCMS 产品操作手册

产品介绍

SD 0006 AI Summary

SD 0006 exhibits various bioactivities, including promising antiinflammatory and antiarthritic properties. In both rat and human models, it reduces LPS-stimulated TNFalpha accumulation, indicating strong antiinflammatory activity. It also demonstrates efficacy against collagen-induced arthritis in a mouse model. As an inhibitor, SD 0006 targets p38alpha (IC50 = 110.0 nM) and p38beta (IC50 = 3450.0 nM) and shows moderate inhibitory effects on human ERG with 16.0% inhibition. The compound also exhibits high bioavailability and favorable pharmacokinetic properties in rat and dog models when administered intravenously, including notable clearance and volume of distribution parameters. Additionally, it has an intrinsic clearance and half-life in human liver microsomes, and a LogD7.4 value of 1.85, reflecting its distribution coefficient. SD 0006 also demonstrates anti-malarial activity, inhibiting Plasmodium falciparum proliferation with potencies ranging from 8407.1 nM to 16774.4 nM. Overall, the compound's bioactivities and pharmacokinetic profile underline its potential as a therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.
靶点活性	p38 MAPK:110 nM (IC50)
别名	SD-06, 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑

化学信息

分子量	397.86
分子式	C₂₀H₂₀ClN₅O₂
CAS No.	271576-80-8
Smiles	OCC(=O)N1CCC(CC1)c1n[nH]c(c1-c1ccncn1)-c1ccc(Cl)cc1
密度	1.367 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 29 mg/mL (72.89 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5134 mL	12.5672 mL	25.1345 mL	125.6723 mL
5 mM	0.5027 mL	2.5134 mL	5.0269 mL	25.1345 mL
10 mM	0.2513 mL	1.2567 mL	2.5134 mL	12.5672 mL
20 mM	0.1257 mL	0.6284 mL	1.2567 mL	6.2836 mL
50 mM	0.0503 mL	0.2513 mL	0.5027 mL	2.5134 mL