Ethoxyquin

Name: Ethoxyquin
Brand: TargetMol
SKU: T0756
Price: 247 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.73%

货号 T0756Cas号 91-53-2

别名 乙氧基喹啉, Santoquin, Santoflex, Quinol

Ethoxyquin (Santoflex) 是一种热休克蛋白 90 抑制剂，是一种用于动物饲料的抗氧化剂。

Ethoxyquin

一键复制产品信息

很棒

纯度: 98.73%

货号 T0756 别名 乙氧基喹啉, Santoquin, Santoflex, QuinolCas号 91-53-2

Ethoxyquin (Santoflex) 是一种热休克蛋白 90 抑制剂，是一种用于动物饲料的抗氧化剂。

规格	价格	库存
1 g	¥ 247	现货
5 g	¥ 413	现货
1 mL x 10 mM (in DMSO)	¥ 413	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.73%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ethoxyquin AI Summary

Ethoxyquin shows a concentration of 0.41 μM that produces 50% protection against L-HCA-mediated neurotoxicity in the HT-22 hippocampal cell line and a minimum tolerated concentration of 50.0 μM according to the MTT reduction assay in the same cell line. A concentration of 103.0 μM leads to 50% toxicity. The safety ratio of the minimum tolerated concentration to the concentration producing 50% protection is 122.0. After intraperitoneal administration of 150 mg/kg, there is an 80.0% survival rate in NMRI mice, with a body temperature decrease of 1.85 degrees Celsius after 30 minutes. Furthermore, Ethoxyquin acts as a potent inhibitor targeting the Menin-MLL Interaction in MLL-related leukemias, modulates Lamin A splicing, affects cell viability in multiple assays, and inhibits various enzymes such as HSD17B4, JMJD2E, and Tyrosyl-DNA Phosphodiesterase. It affects several receptors and signaling pathways, including retinoid X receptor, estrogen receptor, androgen receptor, peroxisome proliferator-activated receptors, and p53 signaling. The compound shows activity against targets like HIV-1 protein Vpr and Trypanosoma brucei and participates in processes like DNA re-replication and gametocytocidal effects. Additionally, Ethoxyquin inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, with an inhibition percentage of 108.27% and 119.72%, respectively, at a concentration of 10 μM. Lastly, it shows lower activity relative to arbidol control in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.6516 after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
别名	乙氧基喹啉, Santoquin, Santoflex, Quinol

化学信息

分子量	217.31
分子式	C₁₄H₁₉NO
CAS No.	91-53-2
Smiles	CCOc1ccc2NC(C)(C)C=C(C)c2c1
密度	1.03
颜色	Yellow
物理性状	Liquid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (253.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (15.19 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6017 mL	23.0086 mL	46.0172 mL	230.0861 mL
5 mM	0.9203 mL	4.6017 mL	9.2034 mL	46.0172 mL
10 mM	0.4602 mL	2.3009 mL	4.6017 mL	23.0086 mL
20 mM	0.2301 mL	1.1504 mL	2.3009 mL	11.5043 mL
50 mM	0.0920 mL	0.4602 mL	0.9203 mL	4.6017 mL
100 mM	0.0460 mL	0.2301 mL	0.4602 mL	2.3009 mL