PD 174265

Name: PD 174265
Brand: TargetMol
SKU: T28339
Price: 128 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.51%

货号 T28339Cas号 216163-53-0

别名 PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

PD 174265 是一种有效、选择性和可逆的表皮生长因子受体 (EGFR) 抑制剂，IC50 为 0.45 nM。

为众多的药物研发团队赋能，

让新药发现更简单！

PD 174265

一键复制产品信息

很棒

纯度: 99.51%

货号 T28339 别名 PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamideCas号 216163-53-0

PD 174265 是一种有效、选择性和可逆的表皮生长因子受体 (EGFR) 抑制剂，IC50 为 0.45 nM。

规格	价格	库存
2 mg	¥ 128	现货
5 mg	¥ 198	现货
10 mg	¥ 269	现货
25 mg	¥ 397	现货
50 mg	¥ 563	现货
1 mL x 10 mM (in DMSO)	¥ 229	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.51%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

PD 174265 AI Summary

PD 174265 is a multi-target kinase inhibitor with varied bioactivities. It effectively inhibits the EphB2 receptor tyrosine kinase, as demonstrated in an ELISA assay with an IC50 value of 180,000 nM. The compound shows potent inhibition of the EGFR with an IC50 of 0.43 nM and retains activity against the drug-resistant EGFR-T790M mutant with an IC50 of 360 nM. Against chicken cSrc, PD 174265 has an IC50 of 6,400 nM for the single mutant and exhibits significantly reduced potency with an IC50 greater than 50,000 nM for the drug-resistant double mutant. Moreover, PD 174265 demonstrates notable bioactivity in growth inhibition assays: it inhibits the growth of human A431 cells with a GI50 of 21.0 nM after 72 hours, induces cell cycle arrest, and triggers apoptosis in these cells. Specifically, it arrests 60.0% of cells in the G1 phase, 12.3% in the G2/M phase, and 27.7% in the S phase at 1 µM concentration after 24 hours, and induces early apoptotic cells (18.0%) and late apoptotic/necrotic cells (3.9%) after 12 hours at the same concentration. The compound also shows inhibitory effects on wild type and mutant EGFR with varying GI50 values in mouse BA/F3 cells expressing different EGFR mutations, demonstrating lower GI50 values (< 500.0 nM) for cells with certain mutations and higher values (> 5000.0 nM) for others, highlighting its potential application as a targeted therapeutic in EGFR-related conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.
别名	PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

化学信息

分子量	371.23
分子式	C₁₇H₁₅BrN₄O
CAS No.	216163-53-0
Smiles	CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
密度	1.31g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (26.94 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6937 mL	13.4687 mL	26.9375 mL	134.6874 mL
5 mM	0.5387 mL	2.6937 mL	5.3875 mL	26.9375 mL
10 mM	0.2694 mL	1.3469 mL	2.6937 mL	13.4687 mL
20 mM	0.1347 mL	0.6734 mL	1.3469 mL	6.7344 mL