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PD 174265

Name: PD 174265
Brand: TargetMol
SKU: T28339
Price: 128 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

货号 T28339Cas号 216163-53-0 一键复制产品信息纯度: 99.51%

很棒

PD 174265 是一种有效、选择性和可逆的表皮生长因子受体 (EGFR) 抑制剂，IC50 为 0.45 nM。

PD 174265

一键复制产品信息

很棒

纯度: 99.51%

货号 T28339Cas号 216163-53-0

别名 PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

PD 174265 是一种有效、选择性和可逆的表皮生长因子受体 (EGFR) 抑制剂，IC50 为 0.45 nM。

规格	价格	库存
2 mg	¥ 128	现货
5 mg	¥ 198	现货
10 mg	¥ 269	现货
25 mg	¥ 397	现货
50 mg	¥ 563	现货
1 mL x 10 mM (in DMSO)	¥ 229	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.51%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

PD 174265 AI Summary

PD 174265 is a multi-target kinase inhibitor with varied bioactivities. It effectively inhibits the EphB2 receptor tyrosine kinase, as demonstrated in an ELISA assay with an IC50 value of 180,000 nM. The compound shows potent inhibition of the EGFR with an IC50 of 0.43 nM and retains activity against the drug-resistant EGFR-T790M mutant with an IC50 of 360 nM. Against chicken cSrc, PD 174265 has an IC50 of 6,400 nM for the single mutant and exhibits significantly reduced potency with an IC50 greater than 50,000 nM for the drug-resistant double mutant. Moreover, PD 174265 demonstrates notable bioactivity in growth inhibition assays: it inhibits the growth of human A431 cells with a GI50 of 21.0 nM after 72 hours, induces cell cycle arrest, and triggers apoptosis in these cells. Specifically, it arrests 60.0% of cells in the G1 phase, 12.3% in the G2/M phase, and 27.7% in the S phase at 1 µM concentration after 24 hours, and induces early apoptotic cells (18.0%) and late apoptotic/necrotic cells (3.9%) after 12 hours at the same concentration. The compound also shows inhibitory effects on wild type and mutant EGFR with varying GI50 values in mouse BA/F3 cells expressing different EGFR mutations, demonstrating lower GI50 values (< 500.0 nM) for cells with certain mutations and higher values (> 5000.0 nM) for others, highlighting its potential application as a targeted therapeutic in EGFR-related conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.
别名	PD-174265, PD174265, N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide

化学信息

分子量	371.23
分子式	C₁₇H₁₅BrN₄O
CAS No.	216163-53-0
Smiles	CCC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 10 mg/mL (26.94 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6937 mL	13.4687 mL	26.9375 mL	134.6874 mL
5 mM	0.5387 mL	2.6937 mL	5.3875 mL	26.9375 mL
10 mM	0.2694 mL	1.3469 mL	2.6937 mL	13.4687 mL
20 mM	0.1347 mL	0.6734 mL	1.3469 mL	6.7344 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。