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Piperacetazine

Name: Piperacetazine
Brand: TargetMol
SKU: T3085
Price: 218 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T3085Cas号 3819-00-9

别名 哌西他嗪, Quide, Psymod, Piperacetazinum

Piperacetazine (Piperacetazinum) 是抗精神病试剂的前体，可用于研究精神分裂症。

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Piperacetazine

一键复制产品信息

很棒

纯度: 99.92%

货号 T3085 别名 哌西他嗪, Quide, Psymod, PiperacetazinumCas号 3819-00-9

Piperacetazine (Piperacetazinum) 是抗精神病试剂的前体，可用于研究精神分裂症。

规格	价格	库存
1 mg	¥ 218	现货
2 mg	¥ 297	现货
5 mg	¥ 496	现货
10 mg	¥ 795	现货
25 mg	¥ 1,330	现货
50 mg	¥ 1,990	现货
100 mg	¥ 2,980	待询
1 mL x 10 mM (in DMSO)	¥ 546	现货

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纯度: 99.92%

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COA LCMS HNMR 产品操作手册

产品介绍

Piperacetazine AI Summary

Piperacetazine exhibits a diverse range of bioactivities across multiple biological targets and pathways. It shows notable inhibition potential against Menin-MLL interaction in MLL-related leukemias (potency of 25178.5 nM), Ubiquitin-specific Protease USP2a (5011.9 nM), Cytochrome P450 2D6 (199.5 nM), Chronic Active B-Cell Receptor Signaling (20596.2 nM), and 15-human lipoxygenase 2 (15-hLO-2) (12589.3 nM). Additionally, it demonstrates delayed death inhibition of the malarial parasite plastid with potencies between 5725.5 nM and 10417.9 nM, inhibition of Cell Surface uPA Generation (10000.0 nM), and induces DNA re-replication in various cell types (631.0 nM to 32642.7 nM). It also impedes Ebola Virus entry (AC50 from 2.818 µM to 9.68 µM). In the context of SARS-CoV-2, Piperacetazine shows antiviral action, although the results vary. It inhibits SARS-CoV-2 cytotoxicity in Caco-2 cells with a modest inhibition percentage of -6.36% at 10 µM. It demonstrates inhibition against SARS-CoV-2 in HRCE cells, with moderate activity and a hit score of 0.01497, and suppresses SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of -5.056%. In VERO-E6 cells, it inhibits virus-induced cytotoxicity with IC50 values ranging from 12,589.25 nM to 16,218.1 nM and demonstrates cell toxicity with a CC50 of 12,200.0 nM. Furthermore, Piperacetazine acts as a potent inhibitor of the human HDAC6 enzyme, with significant inhibition percentages (38.43% to 77.68%) and an IC50 value of 2187.0 nM. It also presents high binding affinity towards several receptors, including HRH1, DRD2, ADRA1A, ADRA1C, DRD3, and HRH3 (AC50 from 13.0 nM to 180.0 nM), displaying both agonist (HTR2A) and antagonist (HTR2B, CNR1, HTR1A) activities, and inhibits targets like PTGS2 and PDE3A. Despite its broad spectrum of activities, Piperacetazine has moderate liver toxicity (39.0% hepatotoxicity) but does not exhibit severe liver conditions like acute or chronic hepatitis, cirrhosis, or steatosis. It has a negative inhibition index against SARS-CoV-2 in Vero E6 cells, indicating no significant effect on cell viability in these conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Piperacetazine (Piperacetazinum), an antipsychotic prodrug, is used forschizophrenia.
别名	哌西他嗪, Quide, Psymod, Piperacetazinum

化学信息

分子量	410.57
分子式	C₂₄H₃₀N₂O₂S
CAS No.	3819-00-9
Smiles	CC(=O)c1ccc2Sc3ccccc3N(CCCN3CCC(CCO)CC3)c2c1
密度	1.0802 g/cm3 (Estimated)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 6.55 mg/mL (15.95 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4356 mL	12.1782 mL	24.3564 mL	121.7819 mL
5 mM	0.4871 mL	2.4356 mL	4.8713 mL	24.3564 mL
10 mM	0.2436 mL	1.2178 mL	2.4356 mL	12.1782 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Piperacetazine Inhibitor inhibit DopamineReceptor Dopamine Receptor Dopamine 5HTReceptor 5HT Receptor 5-HT

Piperacetazine

Piperacetazine

Piperacetazine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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