Abacavir

Name: Abacavir
Brand: TargetMol
SKU: T1267
Price: 279 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.81%

货号 T1267Cas号 136470-78-5

别名 阿巴卡韦, Ziagen, Epzicom

Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。

Abacavir

一键复制产品信息

很棒

纯度: 99.81%

货号 T1267 别名 阿巴卡韦, Ziagen, EpzicomCas号 136470-78-5

Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。

规格	价格	库存
5 mg	¥ 279	现货
10 mg	¥ 393	现货
25 mg	¥ 659	现货
50 mg	¥ 898	现货
100 mg	¥ 1,130	现货
200 mg	¥ 1,430	现货
500 mg	¥ 2,430	现货
1 g	¥ 3,620	现货
1 mL x 10 mM (in DMSO)	¥ 323	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Abacavir AI Summary

Abacavir exhibits broad antiviral activity and cytostatic properties across various viral strains and cell lines. It demonstrates significant efficacy against HIV-1 Reverse Transcriptase, including both wild type and M184V mutant with EC50 values of 5300.0 nM and 15500.0 nM, respectively. Its activity against HIV-1 replication in CEM cells is notable, with an EC50 of 1600.0 nM and a cytotoxicity CC50 of 83000.0 nM. Furthermore, it shows antiviral activity against HIV-2 with EC50 values ranging from 3000.0 nM to 7300.0 nM, and herpes simplex virus types 1 and 2. In HBV mutants, Abacavir achieves 80.0% and 72.0% inhibition against M204I and L180M/M204V mutants, respectively, with an overall EC50 of 3400.0 nM. Additionally, it is potent against multidrug-resistant HIV-1 strains, demonstrated by fold change values ranging from 1.4 to 29.0 relative to wild type. The compound also shows high oral bioavailability at 86.0% in humans, suggesting effective systemic uptake when administered orally. Abacavir displays inhibitory effects on different enzymes and receptors, including Histone Lysine Methyltransferase G9a, and exhibits liver toxicity as indicated by a high DILI severity score of 8.0. It shows relatively low clearance rates and short half-life in humans. The compound's pharmacokinetic profile reveals gender-specific differences in drug metabolism. Despite its antiviral properties, Abacavir has a moderate bioactivity profile, with some cytotoxicity against various human cell lines and a non-significant inhibition of P-gp. It has limited binding affinity for human serum albumin and shows potential hepatotoxicity based on liver function tests. Additionally, Abacavir has an IC50 value greater than 20000.0 nM for SARS-CoV-2, indicating low potency in this context. Overall, these characteristics underscore its potential for further development in antiviral therapies, albeit with considerations for associated hepatotoxic risks..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.
别名	阿巴卡韦, Ziagen, Epzicom

化学信息

分子量	286.33
分子式	C₁₄H₁₈N₆O
CAS No.	136470-78-5
Smiles	N(C1=C2C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)=NC(N)=N1)C4CC4
密度	1.70 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (873.12 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.98 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4925 mL	17.4624 mL	34.9247 mL	174.6237 mL
5 mM	0.6985 mL	3.4925 mL	6.9849 mL	34.9247 mL
10 mM	0.3492 mL	1.7462 mL	3.4925 mL	17.4624 mL
20 mM	0.1746 mL	0.8731 mL	1.7462 mL	8.7312 mL
50 mM	0.0698 mL	0.3492 mL	0.6985 mL	3.4925 mL
100 mM	0.0349 mL	0.1746 mL	0.3492 mL	1.7462 mL