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RPW-24

Name: RPW-24
Brand: TargetMol
SKU: T7669
Price: 262 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 97.21%

货号 T7669Cas号 1001625-82-6

RPW-24 刺激线虫的宿主免疫反应，保护秀丽隐杆线虫免受细菌感染。它具有抗菌活性。

为众多的药物研发团队赋能，

让新药发现更简单！

RPW-24

一键复制产品信息

很棒

纯度: 97.21%

货号 T7669Cas号 1001625-82-6

RPW-24 刺激线虫的宿主免疫反应，保护秀丽隐杆线虫免受细菌感染。它具有抗菌活性。

规格	价格	库存
1 mg	¥ 262	现货
5 mg	¥ 653	现货
10 mg	¥ 1,030	现货
25 mg	¥ 1,680	现货
50 mg	¥ 2,350	现货
100 mg	¥ 3,180	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 97.21%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

化学信息

分子量	284.74
分子式	C₁₅H₁₃ClN₄
CAS No.	1001625-82-6
Smiles	Cc1ccc(Nc2nc(N)c3ccccc3n2)cc1Cl
密度	1.378 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (158.04 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5120 mL	17.5599 mL	35.1198 mL	175.5988 mL
5 mM	0.7024 mL	3.5120 mL	7.0240 mL	35.1198 mL
10 mM	0.3512 mL	1.7560 mL	3.5120 mL	17.5599 mL
20 mM	0.1756 mL	0.8780 mL	1.7560 mL	8.7799 mL
50 mM	0.0702 mL	0.3512 mL	0.7024 mL	3.5120 mL
100 mM	0.0351 mL	0.1756 mL	0.3512 mL	1.7560 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

RPW-24 exhibits multiple bioactivities with significant potential for anti-malarial, anti-leishmanial, anti-trypanosomal, and anti-mycobacterial applications. It inhibits the proliferation of Plasmodium falciparum (3D7 strain) with an EC50 of 527.0 nM and drug-resistant W2 strain with an EC50 of 755.0 nM, demonstrating its effectiveness against both drug-susceptible and drug-resistant malaria strains. The compound also shows low cytotoxicity against Huh7 hepatocellular carcinoma cells with a CC50 of 8920.0 nM. Additionally, RPW-24 is active against Leishmania infantum with an IC50 of 4000.0 nM, Trypanosoma cruzi with an IC50 of 3809.44 nM, and Trypanosoma brucei strains with IC50 values ranging from 3346.97 nM to 6531.06 nM. Though it shows low activity against non-replicating Mycobacterium tuberculosis (Mtb) with an MIC90 > 100,000.0 nM, it exhibits moderate activity against replicating Mtb with an MIC90 of 24700.0 nM. The compound has a lower LD50 of 10.9 µM against HepG2 cells, indicating moderate toxicity, and effectively inhibits parasites like Cryptosporidium parvum with a 40.42% inhibition rate and Schistosoma mansoni somules at a concentration of 2.5 µM. RPW-24 displays substantial anti-HIV bioactivity against CCR5-tropic and CXCR4-tropic strains and cytotoxicity against U87-CD4-CXCR4 and U87-CD4-CCR5 cells. It also shows promising effects in inhibiting the proliferation of various cancer cell lines, including ovarian, renal, breast, colon, melanoma, leukemia, non-small cell lung cancer, prostate, and CNS cancers, with inhibition percentages ranging from 23% to over 100%. Further bioactivities include a significant inhibition of the hERG Kv11.1 channel with 85.0% inhibition at 11.1 µM, anti-babesial activity with IC50 values between 6310.0 nM and 16520.0 nM, inhibition of typical and atypical growth of S. cerevisiae strain JHY222, and moderate inhibition of Plasmodium falciparum gametocyte and ookinete development. While the compound exhibits limited protein kinase inhibition, it does exhibit an IC50 of 1105.0 nM against P. falciparum Dd2-luc strain and shows low potency against glucose transporter-deficient transgenic Leishmania Mexicana promastigotes. These diverse activities display the compound's potential as a broad-spectrum antiparasitic and therapeutic agent across various infectious and non-infectious disease models..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

RPW-24 RPW24 RPW 24 Inhibitor inhibit Bacterial

RPW-24

RPW-24

RPW-24 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词