CSRM617

Name: CSRM617
Brand: TargetMol
SKU: T10896
Rating: 4.5 (1 reviews)

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产品编号 T10896Cas号 787504-88-5

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.

CSRM617

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产品编号 T10896Cas号 787504-88-5

规格	价格	库存
25 mg	¥ 10,600	5日内发货
50 mg	¥ 13,800	5日内发货
100 mg	¥ 17,500	5日内发货

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产品描述	CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
体外活性	CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells. CSRM617 (10-20 μM; 48 hours) induces 22Rv1 cell apoptosis, leading to concentration-dependent cell death . CSRM617 (20 μM; 72 hours) induced 22Rv1 cell apoptosis by cleaving the presence of Caspase-3 and PARP.