(S)-p38 MAPK Inhibitor III

Name: (S)-p38 MAPK Inhibitor III
Brand: TargetMol
SKU: T35420
Rating: 4.5 (1 reviews)

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货号 T35420Cas号 581098-48-8

别名 (S)-p38 MAPK Inhibitor III

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).

(S)-p38 MAPK Inhibitor III

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货号 T35420 别名 (S)-p38 MAPK Inhibitor IIICas号 581098-48-8

规格	价格	库存
500 μg	¥ 1,720	35日内发货
1 mg	¥ 3,290	35日内发货
5 mg	¥ 13,500	35日内发货
10 mg	¥ 23,600	35日内发货

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产品介绍

生物活性

产品描述	(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).
靶点活性	p38 MAPk:0.9 μM
别名	(S)-p38 MAPK Inhibitor III

化学信息

分子量	404.5
分子式	C₂₃H₂₁FN₄S
CAS No.	581098-48-8
密度	1.30 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: 12 mg/mL (29.67 mM), Sonication is recommended. Ethanol: 30 mg/mL (74.17 mM), Sonication is recommended. Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL (0.82 mM), Sonication is recommended. DMF: 20 mg/mL (49.44 mM), Sonication is recommended.
体内实验配方	10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.47 mM), Sonication is recommeded. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。