按潜在通路靶点分类

ChemDiv’s RNA-Protein Interaction Inhibitors Library contains 2,111 compounds.

ChemDiv开发了RNA等位三核苷酸模拟物库，该化合物库包含29000个小分子化合物，专门用于靶向RNA 扩展重复序列。

Life Chemicals has developed its RNA Screening Library of over 4,400 drug-like compounds with predicted RNA-binding activity as an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

Life Chemicals has designed a library of potential GPCR modulators based on known structure and activity data for GPCR targeting compounds available publicly.

Over 2,500 screening compounds of potential helicase inhibitors were selected, with the most active compounds placed at the top of the list.

Cysteine Protease Focused Library comprises over 3,700 screening compounds with potential inhibitory activity against cysteine proteases.

ATP酶靶向库，其中包含超过13,500个类似药物的筛选化合物。

Life Chemicals has designed a novel Screening Library of GPCR targeting compounds intended for screening in GPCR-related drug discovery projects.

ChemDiv’s Antiviral Library contains 87,000 compounds.

含2.1万种潜在活性小分子化合物，是表观转录组学、免疫系统和中枢神经系统疾病相关研究的有力工具。

Life Chemicals has designed a new Tyrosine Kinase Screening Library of about 5,700 drug-like screening compounds offered for high throughput screening (HTS).

Serine proteases are one of the most biologically important families of proteins that have been shown to play multifarious roles in various diseases (such as cancer proliferation, auto-immune disorders, and allergy).

Over 17,000 structurally diverse molecules with potential polymerase inhibition activity.

The Matrix Metalloproteinase Focused Library contains over 2,000 screening compounds.

Life Chemicals offers its new Chelator Library (over 5,700 compounds) that is based on a variety of metal-binding groups.

Tubulin Inhibitors library in UORSY contains 2003 compounds.

GSK3BETA Focused Library in the Princeton BioMolecal Research contains 544 compounds.

ADK Focused Library in the Princeton BioMolecal Research contains 146 compounds.

iPPI Bayesian Library with 2637 compounds was prepared using Bayesian modeling (ECFP6 and FCFP6 fingerprints) based on known active PPI inhibitors (IC50<100 nM) taken from the TIMBAL database.

OTAVAchemicals offers SARS-CoV-2 RNA-dependent RNA Polymerase (RdRp) Targeted Library, which contains 1031 compounds with predicted activity against SARS-CoV-2 RdRp.

ChemDiv’s Antimitotic Tubulin Library contains 18,000 compounds.

Mitogen-activated protein kinase 1 (MAPK1 ERK2) inhibitor library contains 197 compounds.

ChemDiv designed a novel library of 5000 compounds

利用我们在合成trans-十氢萘相关的多氧骨架方面的努力，我们开发了一个非含氮化合物库，用于筛选传统上需要碱性化合物的GPCR靶点。

ChemDiv’s PTPs-targeted library contains 15,000 compounds and design at CDL involves:

OTAVAchemicals offers a high-quality PDZ Domain Targeted Library.

激酶ATP位点结合剂筛选库包含24000个化合物，旨在发现新型激酶ATP 口袋结合物。

We offer SARS-CoV-2 Endoribonuclease (NSP15) Targeted Library, which contains 626 compounds.

OTAVAchemicals 11β-HSD1 Targeted Library (924 compounds) has been designed with flexible molecular docking.

ChemDiv’s Proline Kinase Library contains 2,000 compounds.

ChemDiv’s Autophagy-Targeted Library contains 4,550 compounds.

OTAVAchemicals offers Enhancer of Zeste Homolog 2 (EZH2) Targeted Library. It contains 979 compounds with predicted inhibitory activity against this enzyme.

OTAVAchemicals offers Transporter Modulators Library (525 compounds).

The database contains 190k small molecules divided into 23 sub libraries each focused at a specific target. According to the recent studies, molecules acting on a particular target or class of targets usually have characteristic moieties (PF) containing key binding points responsible for activity, e.g. hinge-binding fragments. We used this principle for the statistical analysis of the reported active molecules and corresponding targets for the annotation of pre-filtered ChemDiv in house collection. The library includes the following targets: Enzymes: Aminoacyltransferase, Hydrolases, Isomerases, Kinases, Ligases, Lyases, Oixireductases, Phosphatases, Proteases, Transferases, Phosphodiesterases; Membrane Receptors: βAmyloid A4 protein, Family A GPCR, Family B GPCR, Family C GPCR, Frizzled family GPCR, Taste family GPCR, σOpioid receptor, Thrombopoietin receptor; Ion channels: Voltage-gated, Ligand-gated; Epigenetic regulator.

Antimycobacterial library in Otava contains 1696 compounds

Tryptase targeted library in Otava contains 139 compounds

Adenosine receptor antagonist library in Otava contains 110 compounds

OTAVAchemicals offers Selective Androgen Receptor Modulators-Like Library (1233 compounds in total).

MAP kinase (MAPK) inhibitor library in Otava contains 102 compounds

Bromodomain-containing protein 4 (BRD4) inhibitor library contains 401 compounds.

Estrogen receptor α β (ERα ERβ) agonist library in Otava contains 556 compounds.