Hydrocortisone 17-butyrate

Name: Hydrocortisone 17-butyrate
Brand: TargetMol
SKU: T0270
Price: 110 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.57%

货号 T0270Cas号 13609-67-1

别名 丁酸氢化可的松, Hydrocortisone butyrate, Cortisol 17-butyrate

Hydrocortisone 17-butyrate (Cortisol 17-butyrate) 是一种肾上腺皮质激素类药物。

Hydrocortisone 17-butyrate

一键复制产品信息

很棒

纯度: 99.57%

货号 T0270 别名 丁酸氢化可的松, Hydrocortisone butyrate, Cortisol 17-butyrateCas号 13609-67-1

Hydrocortisone 17-butyrate (Cortisol 17-butyrate) 是一种肾上腺皮质激素类药物。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 198	现货
100 mg	¥ 289	现货
500 mg	¥ 678	待询
1 mL x 10 mM (in DMSO)	¥ 110	现货

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纯度: 99.57%

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COA HNMR HPLC LCMS 产品操作手册

产品介绍

Hydrocortisone 17-butyrate AI Summary

Hydrocortisone 17-butyrate exhibits notable potency in several pharmacological assays. It shows significant vasoconstrictor potency in humans at a level of 50.0 compared to fluocinolone 16,17-acetonide and demonstrates an anti-inflammatory effect in the rat granuloma assay at a potency comparable to hydrocortisone and hydrocortisone 21-acetate. Moreover, it has a measurable binding affinity to the glucocorticoid receptor of rat thymus cytosol, with a relative affinity of 12.4, suggesting glucocorticoid receptor modulation activity. In terms of biochemical interactions, Hydrocortisone 17-butyrate binds moderately to beta cyclodextrin with a log Ks value of 3.23. It influences several molecular pathways and exhibits varied bioactivities, including miRNA modulation, inhibition of Cruzain, Nrf2 inhibition, and inhibition of HP1-beta chromodomain interactions with methylated histone tails. Notably, it shows potent antiviral activities against SARS-CoV-2, inhibiting virus-induced cytotoxicity in several cell types and interfering with the virus's protease activity and entry mechanisms. Additionally, it impacts cellular transport proteins, showing over 98% inhibition of sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells. This compound also demonstrates various activities such as inducing DNA re-replication in cancer cells and inhibiting Pin1 and ATXN expression, reflecting its broad therapeutic potential across multiple pathways and diseases. Finally, Hydrocortisone 17-butyrate has agonist activity at human PGR (progesterone receptor) with an AC50 of 42.0 nM but does not show significant inhibition in several other receptor and enzyme assays, highlighting its specific bioactivity profile in targeted pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
别名	丁酸氢化可的松, Hydrocortisone butyrate, Cortisol 17-butyrate

化学信息

分子量	432.55
分子式	C₂₅H₃₆O₆
CAS No.	13609-67-1
Smiles	CCCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
密度	1.0914 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (288.98 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.25 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3119 mL	11.5594 mL	23.1187 mL	115.5936 mL
5 mM	0.4624 mL	2.3119 mL	4.6237 mL	23.1187 mL
10 mM	0.2312 mL	1.1559 mL	2.3119 mL	11.5594 mL
20 mM	0.1156 mL	0.5780 mL	1.1559 mL	5.7797 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3119 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1559 mL