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Urapidil hydrochloride

Name: Urapidil hydrochloride
Brand: TargetMol
SKU: T0088
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.58%

货号 T0088Cas号 64887-14-5

别名 盐酸乌拉地尔, Urapidil HCl

Urapidil hydrochloride (Urapidil HCl) 是α1-肾上腺素受体拮抗剂和5-HT1A 受体激动剂。

Urapidil hydrochloride

一键复制产品信息

很棒

纯度: 99.58%

货号 T0088 别名 盐酸乌拉地尔, Urapidil HClCas号 64887-14-5

Urapidil hydrochloride (Urapidil HCl) 是α1-肾上腺素受体拮抗剂和5-HT1A 受体激动剂。

规格	价格	库存
25 mg	¥ 123	现货
50 mg	¥ 173	现货
100 mg	¥ 276	现货
500 mg	¥ 686	现货
1 g	¥ 1,030	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.58%

颜色: 白色

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资源下载:

COA LCMS HPLC HNMR 产品操作手册

产品介绍

Urapidil hydrochloride AI Summary

Urapidil hydrochloride exhibits a broad spectrum of bioactive properties. It has shown antiplasmodial activity against Plasmodium falciparum strains 3D7 and W2 with IC50 values of 12,589.25 nM and 10,000.0 nM, respectively, after 72 hours as determined by SYBR green assay. Additionally, it is a potent differential inhibitor of various Plasmodium falciparum lines including 3D7, W2, GB4, D10, and HB3. The compound also demonstrates significant inhibitory effects on multiple bio targets including APE1, lipid storage modulation in Drosophila S3 cells, tau fibril formation, myelin protein 22, histone lysine methyltransferase G9a, Bloom's syndrome helicase (BLM), and the delayed death of the malarial parasite plastid. Furthermore, it shows activity against the interaction between CBF-beta and RUNX1 in acute myeloid leukemia treatment, as well as inhibitory effects on cellular entry of Marburg Virus, Glutaminase (GLS), and Ebola Virus, with potencies ranging from 12.6 nM to over 89,000 nM. Urapidil hydrochloride also exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a 6.88% inhibition rate at 10 μM after 48 hours and in VERO-6 cells with an inhibition of -0.11% at 10 μM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus, as measured by high content imaging. Its activity against SARS-CoV-2 3CL-Pro protease shows an inhibition percentage of 8.021%. Additionally, it has been tested for bioactivity in inhibiting cell viability in SARS-CoV-2 infected Vero E6 cells, displaying an inhibition index of 0.607 relative to the arbidol control. In antifungal assays, Urapidil hydrochloride showed inhibition percentages of 3.19% against Candida albicans and -6.92% against Cryptococcus neoformans. For antibacterial activity, it demonstrated inhibition percentages against Escherichia coli (0.81%), Klebsiella pneumoniae (17.15%), Pseudomonas aeruginosa (19.16%), Acinetobacter baumannii (26.15%), and Staphylococcus aureus MRSA (12.2%)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
靶点活性	α1-adrenoceptor:6.13 (pIC50), 5-HT1A receptor:6.4 (pIC50), α2-adrenoceptor:4.38 (pIC50)
别名	盐酸乌拉地尔, Urapidil HCl

化学信息

分子量	423.94
分子式	C₂₀H₂₉N₅O₃·HCl
CAS No.	64887-14-5
Smiles	Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 8.33 mg/mL (19.65 mM), Sonication is recommended.

H2O: 200.5 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3588 mL	11.7941 mL	23.5882 mL	117.9412 mL
5 mM	0.4718 mL	2.3588 mL	4.7176 mL	23.5882 mL
10 mM	0.2359 mL	1.1794 mL	2.3588 mL	11.7941 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1179 mL	0.5897 mL	1.1794 mL	5.8971 mL
50 mM	0.0472 mL	0.2359 mL	0.4718 mL	2.3588 mL
100 mM	0.0236 mL	0.1179 mL	0.2359 mL	1.1794 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

α-adrenergic receptor Urapidil Hydrochloride Urapidil Serotonin Receptor Inhibitor inhibit Beta Receptor antihypertensive effect AdrenergicReceptor Adrenergic Receptor 5-hydroxytryptamine Receptor 5HTReceptor 5-HT Receptor 5HT Receptor 5-HT

Urapidil hydrochloride

Urapidil hydrochloride