Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1]. |
体外活性 | STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC 50 s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively [1]. STAT3-IN-9 (0, 0.2, 1.0, 5.0 μM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701) [1]. STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway [1]. STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner [1]. Cell Proliferation Assay [1] Cell Line: MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells Concentration: Incubation Time: 48 h Result: Showed potent in vitro anti-tumor activity with IC 50 s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively. Western Blot Analysis [1] Cell Line: MDA-MB-468 cells Concentration: 0, 0.2, 1.0, 5.0 μM Incubation Time: 24 h Result: Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). Apoptosis Analysis [1] Cell Line: MDA-MB-468 cells Concentration: 0, 0.2, 1 μM Incubation Time: 24 h Result: Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway. Cell Cycle Analysis [1] Cell Line: MDA-MB-468 cells Concentration: 0, 0.2, 1 μM Incubation Time: 24 h Result: Cells were arrest at the G2/M phase in a dose-dependent manner. |
分子量 | 391.42 |
分子式 | C22H21N3O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
STAT3-IN-9 Inhibitor inhibitor inhibit