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Folinic acid calcium
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很棒纯度: 99.73%
货号 T0148Cas号 1492-18-8
别名 亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate
Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。
Folinic acid calcium
一键复制产品信息 很棒纯度: 99.73%
货号 T0148 别名 亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinateCas号 1492-18-8
Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 mg | ¥ 254 | 现货 | |
| 100 mg | ¥ 458 | 现货 | |
| 200 mg | ¥ 697 | 现货 |
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产品介绍
Folinic acid calcium AI Summary
Folinic acid calcium exhibits significant growth inhibition activity across a diverse array of human tumor cell lines, including those from renal, non-small cell lung, leukemia, melanoma, ovarian, breast, central nervous system, and colon origins. The GI50 values range from 14,791.08 nM to 95,279.62 nM, highlighting its potential as an anti-cancer agent. Additionally, Folinic acid calcium strongly inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells by 80.81% and 90.54%, respectively, at a concentration of 10 µM. It also exhibits weak inhibitory effects on transport proteins such as BSEP, MRP2, MRP3, and MRP4, with IC50 values exceeding 133,000 nM.
In terms of safety, Folinic acid calcium does not induce liver toxicity, as indicated by a severity class index of 0.0 in drug-induced liver injury assays. Furthermore, it shows limited cytotoxicity against Vero E6 cells infected with SARS-CoV-2 at low MOI after 72 hours, and it demonstrates marginal inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-0.23%) and Vero-6 cells (0.03%) at 10 µM concentration after 48 hours. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease by 30.5% at a concentration of 20 µM, as measured by FRET response from a peptide substrate. These characteristics suggest that Folinic acid calcium holds promise for further exploration as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists. |
| 靶点活性 | zmSHMT:70 μM, zcSHMT:30 μM |
| 别名 | 亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate |
| 分子量 | 511.51 |
| 分子式 | C20H21CaN7O7 |
| CAS No. | 1492-18-8 |
| Smiles | [Ca++].Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc2[nH]1 |
| 密度 | no data available |
| 存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | H2O: 9.8 mg/mL (19.16 mM), Sonication is recommended.  DMSO: Insoluble | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
H2O
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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