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Folinic acid calcium

Name: Folinic acid calcium
Brand: TargetMol
SKU: T0148
Price: 254 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate

货号 T0148Cas号 1492-18-8 一键复制产品信息纯度: 99.73%

很棒

Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

Folinic acid calcium

一键复制产品信息

很棒

纯度: 99.73%

货号 T0148Cas号 1492-18-8

别名 亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate

Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

规格	价格	库存
50 mg	¥ 254	现货
100 mg	¥ 458	现货
200 mg	¥ 697	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.73%

颜色: 白色至黄色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Folinic acid calcium AI Summary

Folinic acid calcium exhibits significant growth inhibition activity across a diverse array of human tumor cell lines, including those from renal, non-small cell lung, leukemia, melanoma, ovarian, breast, central nervous system, and colon origins. The GI50 values range from 14,791.08 nM to 95,279.62 nM, highlighting its potential as an anti-cancer agent. Additionally, Folinic acid calcium strongly inhibits the uptake of sodium fluorescein in OATP1B1 and OATP1B3-transfected CHO cells by 80.81% and 90.54%, respectively, at a concentration of 10 µM. It also exhibits weak inhibitory effects on transport proteins such as BSEP, MRP2, MRP3, and MRP4, with IC50 values exceeding 133,000 nM. In terms of safety, Folinic acid calcium does not induce liver toxicity, as indicated by a severity class index of 0.0 in drug-induced liver injury assays. Furthermore, it shows limited cytotoxicity against Vero E6 cells infected with SARS-CoV-2 at low MOI after 72 hours, and it demonstrates marginal inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-0.23%) and Vero-6 cells (0.03%) at 10 µM concentration after 48 hours. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease by 30.5% at a concentration of 20 µM, as measured by FRET response from a peptide substrate. These characteristics suggest that Folinic acid calcium holds promise for further exploration as a multi-target therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
靶点活性	zcSHMT:30 μM, zmSHMT:70 μM
别名	亚叶酸钙, Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate

化学信息

分子量	511.51
分子式	C₂₀H₂₁CaN₇O₇
CAS No.	1492-18-8
Smiles	[Ca++].Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc2[nH]1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 9.8 mg/mL (19.16 mM), Sonication is recommended.

DMSO: Insoluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9550 mL	9.7750 mL	19.5500 mL	97.7498 mL
5 mM	0.3910 mL	1.9550 mL	3.9100 mL	19.5500 mL
10 mM	0.1955 mL	0.9775 mL	1.9550 mL	9.7750 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

VB Thymidylate synthase RNASynthesis RNA Synthesis Leucovorin Inhibitor inhibit Folinic acid calcium Folinic acid EndogenousMetabolite Endogenous Metabolite DNASynthesis DNA Synthesis Antifolate

Folinic acid calcium

Folinic acid calcium