Isovitexin

Name: Isovitexin
Brand: TargetMol
SKU: T6S1371
Price: 352 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.97%

货号 T6S1371Cas号 38953-85-4

别名 异牡荆黄素, Saponaretin, Homovitexin, Apigenin-6-C-Glucoside

Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮，具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似，抑制NF-κB 的活化。

Isovitexin

一键复制产品信息

很棒

纯度: 99.97%

货号 T6S1371 别名 异牡荆黄素, Saponaretin, Homovitexin, Apigenin-6-C-GlucosideCas号 38953-85-4

Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮，具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似，抑制NF-κB 的活化。

规格	价格	库存
1 mg	¥ 352	现货
5 mg	¥ 898	现货
10 mg	¥ 1,430	现货
25 mg	¥ 2,910	现货
50 mg	¥ 4,230	现货
100 mg	¥ 5,890	现货
200 mg	¥ 7,910	现货
1 mL x 10 mM (in DMSO)	¥ 883	现货

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产品介绍

Isovitexin AI Summary

Isovitexin shows strong bioactivity in inhibiting platelet aggregation, demonstrating significant inhibition of thrombin-, arachidonic acid-, collagen-, and platelet-activating factor-induced platelet aggregation in rabbit plasma at a concentration of 300 uM. It also exhibits potent antioxidant activity, with a TEAC value of 0.15 Trolox Units. In various assays, Isovitexin inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) at 19952.6 nM, acts as an agonist for the gsp mutation in Fibrous Dysplasia/McCune-Albright Syndrome at 4466.8 nM, induces synthetic lethality in tumor cells producing 2HG at 29092.9 nM, and inhibits Vaccinia Orthopoxvirus at 1000.0 nM. Additionally, it inhibits acetylcholinesterase (AChE) at 2 mg/ml with 20.74% inhibition and butyrylcholinesterase (BChE) at 2 mg/ml with 1.98% inhibition. It also inhibits alpha-glucosidase activity with a percentage inhibition of 76.84% at concentrations ranging from 50 to 300 ug/mL and an IC50 value of 68.71 ug/mL. Isovitexin shows low cytotoxicity against various human cell lines, with IC50 values greater than 50000.0 nM. It has an IC50 value of 61200.0 nM for inhibiting Bacillus stearothermophilus alpha-glucosidase and a HPLC-SPE-NMR retention time of 19.5 minutes. The compound also inhibits Staphylococcus aureus USA300 Sortase A protease with an IC50 of 28.98 ug/mL and demonstrates antibiofilm activity by inhibiting biofilm formation by 61.0% at a concentration of 256 ug/mL. Moreover, it inhibits the Staphylococcus aureus SrtA enzyme activity with an IC50 of 67020.0 nM as shown in a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
别名	异牡荆黄素, Saponaretin, Homovitexin, Apigenin-6-C-Glucoside

化学信息

分子量	432.38
分子式	C₂₁H₂₀O₁₀
CAS No.	38953-85-4
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1
密度	1.686 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 86.6 mg/mL (200.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.63 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3128 mL	11.5639 mL	23.1278 mL	115.6390 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL	23.1278 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL	11.5639 mL
20 mM	0.1156 mL	0.5782 mL	1.1564 mL	5.7820 mL
50 mM	0.0463 mL	0.2313 mL	0.4626 mL	2.3128 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	1.1564 mL