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Ticlopidine

Name: Ticlopidine
Brand: TargetMol
SKU: T4190
Price: 235 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.67%

货号 T4190Cas号 55142-85-3

别名 噻氯匹定, Ticlid, PCR 5332

Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂，抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂，能够阻断 NTPDase 同工酶，对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。

Ticlopidine

一键复制产品信息

很棒

纯度: 99.67%

货号 T4190 别名 噻氯匹定, Ticlid, PCR 5332Cas号 55142-85-3

规格	价格	库存
5 mg	¥ 235	现货
10 mg	¥ 343	现货
25 mg	¥ 663	现货
50 mg	¥ 970	现货
100 mg	¥ 1,490	现货
500 mg	¥ 3,720	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.67%

颜色: 白色

性状: Solid

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COA HNMR LCMS 产品操作手册

产品介绍

Ticlopidine AI Summary

Ticlopidine exhibits a diverse range of bioactivities, primarily pertaining to its antithrombotic and inhibitory effects on various enzymes and receptors. It demonstrates significant antiplatelet activity by inhibiting collagen and ADP-induced platelet aggregation in both human and rabbit platelet-rich plasma (PRP). Notably, it has an IC50 value of 3180.0 nM against ADP-induced aggregation in rabbits and exhibits inhibitory activities against thrombin-induced platelet aggregation with an IC50 of 1550000.0 nM. In mouse models, Ticlopidine shows an ID50 of 260.0 mg/kg for preventing acute thrombic death induced by collagen. The effective doses (ED50) for antithrombotic activity are 151.64 umol/kg-1 and 40.0 mg/kg-1 in mice. Additionally, it demonstrates high in vivo antithrombotic activity with a PD50 of 120.0 mg/kg and significant inhibition in collagen-induced assays in rats. The compound also shows substantial inhibitory effects on several cytochrome P450 enzymes, including CYP2B6, CYP2C19, CYP3A4, and others, indicating potential drug-drug interaction concerns. It has a Ki value of 200.0 nM for CYP2B6 and demonstrates time-dependent inhibition of CYP2C19 with a Ki of 3300.0 nM and a Kinact of 0.07 min-1. The compound also strongly inhibits human liver microsomal enzymes, with IC50 values of 210.0 nM and 70000.0 nM for CYP2B6 and CYP2C19, respectively. In terms of liver toxicity, Ticlopidine is associated with significant risk, exhibiting a Drug-Induced Liver Injury (DILI) severity score of 4.0. It shows moderate to high hepatotoxicity in markers such as ALT, ALP, AST, and others, contributing to its cytolytic and cholestatic liver toxicity profiles in clinical settings. Additionally, Ticlopidine demonstrates antiviral activity against SARS-CoV-2 and possesses antimicrobial properties, particularly against methicillin-resistant Staphylococcus aureus (MRSA). It shows moderate efficacy in reducing the minimum inhibitory concentration (MIC) and has potential as a therapeutic agent in infectious diseases. Overall, Ticlopidine has demonstrated a broad spectrum of bioactivities, making it a candidate for further pharmacological exploration while also presenting considerations for safety and interaction profiles..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
别名	噻氯匹定, Ticlid, PCR 5332

化学信息

分子量	263.79
分子式	C₁₄H₁₄ClNS
CAS No.	55142-85-3
Smiles	Clc1ccccc1CN1CCc2sccc2C1
密度	1.273 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (208.5 mM), Sonication is recommended.

H2O: Insoluble

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7909 mL	18.9545 mL	37.9089 mL	189.5447 mL
5 mM	0.7582 mL	3.7909 mL	7.5818 mL	37.9089 mL
10 mM	0.3791 mL	1.8954 mL	3.7909 mL	18.9545 mL
20 mM	0.1895 mL	0.9477 mL	1.8954 mL	9.4772 mL
50 mM	0.0758 mL	0.3791 mL	0.7582 mL	3.7909 mL
100 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8954 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Ticlopidine Platelet Aggregation Inhibitor PCR-5332 PCR5332 NTPDase noncompetitive liver cytochrome Inhibitor inhibit Cytochrome P450 CYPs CYP2C19 CD39 antithrombotic prodrug allosteric ADP Adiponectinreceptor Adiponectin receptor

Ticlopidine

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体内实验配液计算器

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