SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.

HDAC5:4.07 μM, HDAC6:2.3 nM, HDAC9:3.46 μM, HDAC11:5.72 μM, HDAC3:29.5 μM, HDAC1:5.23 μM, HDAC2:32.8 μM, HDAC8:3.72 μM, HDAC7:4.55 μM, HDAC10:26.2 μM, HDAC4:10.9 μM

SW-100（0.01-10 μM；48小时）在剂量依赖性方式下显著提高乙酰化α-微管蛋白水平[1]。

在小鼠的脆性X综合征模型中，SW-100（20 mg/kg；i.p.；每天两次，连续两天）改善了包括新奇物体识别、时间排序以及坐标和类别空间处理在内的多个记忆和学习障碍[1]。