Name: PCO371
Brand: TargetMol
SKU: T16442
Price: 428 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 428

现货

5 mg

¥ 793

现货

10 mg

¥ 1,290

现货

25 mg

¥ 2,120

现货

50 mg

¥ 3,480

现货

100 mg

¥ 4,980

现货

1 mL x 10 mM (in DMSO)

¥ 1,130

现货

产品介绍

生物活性

产品描述	PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
靶点活性	LLC-PK1 cells:4.1 mM (EC50), PTHR1 (COS-7 cells):2.4 μM (EC50), hPTHR1-delNT (COS-7 cells):17 μM (EC50)
体外活性	在表达hPTHR1的COS-7细胞中，PCO371引发cAMP产生（EC50：2.4μM）。在转染有hPTHR1-delNT的COS-7细胞中，2.5μM的PCO371同样能增强磷脂酶C活性（EC50，17μM）[1]。
别名	2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

化学信息

分子量	635.65
分子式	C₂₉H₃₂F₃N₅O₆S
CAS No.	1613373-33-3
Smiles	Cc1cc(cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1ccc(OC(F)(F)F)cc1)N1C(=O)NC(=O)C1(C)C
密度	1.47 g/cm3 (Predicted)

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 120 mg/mL (188.78 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5732 mL	7.8660 mL	15.7319 mL	78.6596 mL
5 mM	0.3146 mL	1.5732 mL	3.1464 mL	15.7319 mL
10 mM	0.1573 mL	0.7866 mL	1.5732 mL	7.8660 mL
20 mM	0.0787 mL	0.3933 mL	0.7866 mL	3.9330 mL
50 mM	0.0315 mL	0.1573 mL	0.3146 mL	1.5732 mL
100 mM	0.0157 mL	0.0787 mL	0.1573 mL	0.7866 mL

体内实验配液计算器