Name: CCG-1423
Brand: TargetMol
SKU: T2014
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 153

现货

5 mg

¥ 335

现货

10 mg

¥ 525

现货

25 mg

¥ 933

现货

50 mg

¥ 1,530

现货

100 mg

¥ 2,570

现货

200 mg

¥ 3,880

现货

500 mg

¥ 6,250

5日内发货

1 mL x 10 mM (in DMSO)

¥ 375

现货

产品介绍

生物活性

产品描述	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
靶点活性	LRRK2 (G2019S):1.85 nM, LRRK2 (WT):1.28 nM
体内活性	在H9c2细胞中,CCG-1423抑制MRTF核定位,并完全阻断STARS近端报告基因活性。在人结肠肌成纤维细胞中,CCG-1423抑制TGF-β诱导的纤维增生。小鼠胚胎干细胞在CCG-1423与LY294002作用下,分化为中间中胚层。在RhoC过表达的黑色素瘤细胞(A375M2 和 SK-Mel-147)中,CCG-1423能够选择性抑制细胞增殖。
细胞实验	Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)
别名	CCG1423

化学信息

分子量	454.75
分子式	C₁₈H₁₃ClF₆N₂O₃
CAS No.	285986-88-1
Smiles	CC(ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(Cl)cc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 4 mg/mL (8.79 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 83 mg/mL (182.52 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1990 mL	10.9951 mL	21.9901 mL	109.9505 mL
5 mM	0.4398 mL	2.1990 mL	4.3980 mL	21.9901 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2199 mL	1.0995 mL	2.1990 mL	10.9951 mL
20 mM	0.1100 mL	0.5498 mL	1.0995 mL	5.4975 mL
50 mM	0.0440 mL	0.2199 mL	0.4398 mL	2.1990 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0995 mL

体内实验配液计算器