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Prilocaine hydrochloride

Name: Prilocaine hydrochloride
Brand: TargetMol
SKU: T0796
Price: 110 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.97%

货号 T0796Cas号 1786-81-8

别名 盐酸丙胺卡因, Xylonest, Propitocaine hydrochloride, Prilocaine HCl

Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。

Prilocaine hydrochloride

一键复制产品信息

很棒

纯度: 99.97%

货号 T0796 别名 盐酸丙胺卡因, Xylonest, Propitocaine hydrochloride, Prilocaine HClCas号 1786-81-8

规格	价格	库存
10 mg	¥ 112	现货
25 mg	¥ 173	现货
50 mg	¥ 248	现货
100 mg	¥ 397	现货
500 mg	¥ 978	现货
1 g	¥ 1,450	现货
1 mL x 10 mM (in DMSO)	¥ 110	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.97%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Prilocaine hydrochloride AI Summary

Prilocaine hydrochloride exhibits a broad spectrum of biological activities. It shows significant antiplasmodial activity against Plasmodium falciparum GB4 with an IC50 of 12589.25 nM, and a potency range of 11220.2-14125.4 nM for inhibiting Plasmodium falciparum proliferation. Additionally, it demonstrates potent inhibition of various targets including Lamin A Splicing (25118.9 nM), Tau Fibril Formation (8912.5 nM), HPGD (19952.6 nM), Human alpha-Glucosidase (3981.1 nM), Lipid Storage Modulation (4466.8 nM), beta-arrestin-biased ligands of beta2-adrenergic receptor (3162.3 nM), Eya2 Phosphatase (22387.2 nM), and Histone Lysine Methyltransferase G9a (22.4 nM). It also exhibits inhibitory activity in OATP1B1- and OATP1B3-transfected CHO cells (87.24% and 74.6% inhibition at 10 uM, respectively). Despite showing low activity against SARS-CoV-2 in some assays, it has demonstrated inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-29.5% inhibition at 10 uM) and VERO-6 cells (0.16% inhibition at 10 uM). Prilocaine hydrochloride also inhibits the SARS-CoV-2 3CL-Pro protease by 14.97% at 20µM. Additionally, the compound exhibits antifungal activity against Candida albicans and antibacterial activity against multiple strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA Staphylococcus aureus. Prilocaine hydrochloride is a multifaceted molecule with potential applications in antiplasmodial, antiviral, antifungal, antibacterial therapies, and modulating various biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.
别名	盐酸丙胺卡因, Xylonest, Propitocaine hydrochloride, Prilocaine HCl

化学信息

分子量	256.77
分子式	C₁₃H₂₁ClN₂O
CAS No.	1786-81-8
Smiles	Cl.CCCNC(C)C(=O)Nc1ccccc1C
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (233.67 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8945 mL	19.4727 mL	38.9454 mL	194.7268 mL
5 mM	0.7789 mL	3.8945 mL	7.7891 mL	38.9454 mL
10 mM	0.3895 mL	1.9473 mL	3.8945 mL	19.4727 mL
20 mM	0.1947 mL	0.9736 mL	1.9473 mL	9.7363 mL
50 mM	0.0779 mL	0.3895 mL	0.7789 mL	3.8945 mL
100 mM	0.0389 mL	0.1947 mL	0.3895 mL	1.9473 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

SodiumChannel Sodium potassium pump Sodium Channel Propitocaine Hydrochloride Prilocaine hydrochloride Prilocaine neurotoxic Na+/K+ ATPase Na(+)local K(+)Inhibitor inhibit anaesthetize

Prilocaine hydrochloride

Prilocaine hydrochloride