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Medronic acid

Name: Medronic acid
Brand: TargetMol
SKU: T19415
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.80%

货号 T19415Cas号 1984-15-2

别名 亚甲基二磷酸, Methylenediphosphonic acid

Medronic acid (Methylenediphosphonic acid) 是一种亚甲基取代的二膦酸盐。它对骨基质中的羟基磷灰石晶体的表面具有亲和力，并且可粘附在其表面。它能够在类骨质矿化的位点累积，可以在骨成像中与放射性同位素复合使用。

Medronic acid

一键复制产品信息

很棒

纯度: 99.80%

货号 T19415 别名 亚甲基二磷酸, Methylenediphosphonic acidCas号 1984-15-2

规格	价格	库存	数量
50 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 460	现货

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实验操作小课堂

常见问题解答

选择批次:

纯度: 99.80%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Medronic acid AI Summary

Medronic acid is a multi-targeting molecule with diverse bioactivities. It demonstrates varying binding affinities against ornithine transcarbamoylase (OTC) from Streptococcus faecalis, with Ki values ranging from 9,000,000 nM to greater than 20,000,000 nM depending on pH and buffer conditions. As an activator of human cytosolic carbonic anhydrase I, it has an activation constant (KA) of 0.2 mM, and binds various carbonic anhydrase enzymes with Ki values between 730,000 nM and 5,340,000 nM. Additionally, Medronic acid is a potent inhibitor of Escherichia coli F plasmid TraI relaxase Y16F mutant (Ki = 3.0 nM), DNA transfer between tetracycline-resistant and streptomycin-resistant E. coli strains (EC50 = 350.0 nM), and demonstrates cytotoxicity against tetracycline-resistant (EC50 = 510.0 nM) and streptomycin-resistant (EC50 = 870,000 nM) E. coli strains. Its selectivity ratios range from 0.68 to 1700.0. The compound also shows inhibitory activity against thyroid hormone receptor interaction with steroid receptor coregulator 2, human Jumonji Domain Containing 2E, fructose-1,6-bisphosphate aldolase from Giardia Lamblia, and the ERK signaling pathway. It has activities against HADH2, T. brucei phosphofructokinase, histone lysine methyltransferase G9a, and BAZ2B. Furthermore, Medronic acid inhibits red kidney beans purple acid phosphatase (Ki = 140,000.0 nM) and exerts inhibitory effects against human recombinant carbonic anhydrase 2 and 9 and human recombinant MMP-2 with IC50 values of 1,250,000 nM, 860,000 nM, and 49,000 nM respectively. It binds to hydroxyapatite with a measured concentration range of 3.2 to 3.7 mM after 1 hour, showing an activity level of 70.0%. Moreover, Medronic acid displays antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (10 μM, -5.54% inhibition) and VERO-6 cells (10 μM, with inhibition ranges from -0.08% to -0.1%). It also inhibits the SARS-CoV-2 3CL-Pro protease with inhibition percentages of 3.11% and 2.39% at a 20 µM concentration. Lastly, it shows partial inhibition of human HDAC6 enzymatic activity (18.33% inhibition with a commercial peptide substrate, -13.18% inhibition with a custom peptide substrate)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Medronic acid (Methylenediphosphonic acid), a methylene-substituted bisphosphonate, exhibits affinity for and adherence to hydroxyapatite crystals within the bone matrix. Accumulating at sites of osteoid mineralization, it is utilized, often in conjunction with radioisotopes, for bone imaging.
别名	亚甲基二磷酸, Methylenediphosphonic acid

化学信息

分子量	176
分子式	CH₆O₆P₂
CAS No.	1984-15-2
Smiles	C(P(=O)(O)O)P(=O)(O)O
密度	2.111 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (1420.45 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (28.41 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6818 mL	28.4091 mL	56.8182 mL	284.0909 mL
5 mM	1.1364 mL	5.6818 mL	11.3636 mL	56.8182 mL
10 mM	0.5682 mL	2.8409 mL	5.6818 mL	28.4091 mL
20 mM	0.2841 mL	1.4205 mL	2.8409 mL	14.2045 mL
50 mM	0.1136 mL	0.5682 mL	1.1364 mL	5.6818 mL
100 mM	0.0568 mL	0.2841 mL	0.5682 mL	2.8409 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Medronic acid Inhibitor inhibit

Medronic acid

Medronic acid

Medronic acid 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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