FT001

Name: FT001
Brand: TargetMol
SKU: T27392
Price: 774 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.9%

货号 T27392Cas号 1778655-51-8

FT001是一种有效的、选择性的和具有口服活性的 BET Bromodomain 抑制剂，具有抗肿瘤活性。FT001抑制 MYC 的表达，IC50为0.46 μM。FT001对 MV-4-11具有有效的抗增殖作用，并在体外和体内显著抑制 MYC mRNA 水平。

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FT001

一键复制产品信息

很棒

纯度: 99.9%

货号 T27392Cas号 1778655-51-8

规格	价格	库存
1 mg	¥ 774	现货
2 mg	¥ 1,150	现货
5 mg	¥ 1,790	现货
10 mg	¥ 2,630	现货
25 mg	¥ 4,140	现货
50 mg	¥ 5,690	现货
100 mg	¥ 7,680	现货
500 mg	¥ 15,300	现货
1 mL x 10 mM (in DMSO)	¥ 1,980	现货

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纯度: 99.9%

ee: 100%

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COA LCMS HNMR CSFC 产品操作手册

产品介绍

FT001 AI Summary

FT001 exhibits robust bioactivities, including the inhibition of His-epitope tagged BRD4 bromodomain 1 with an IC50 of 100.0 nM. It shows significant growth inhibition of human MV411 cells, with a GI50 value of 220.0 nM, and inhibits BRD4 in these cells with an IC50 of 460.0 nM, which leads to a reduction in MYC mRNA expression. In stability assays, 95.0% of the parent compound remains intact after 30 minutes in mouse liver microsomes, and it has a plasma half-life of over 0.4 hours in mice. The compound's MTD in orally dosed athymic Hsd:Foxn1nu mice is 12.5 mg/kg. At this dosage, it also demonstrates the ability to reduce MYC mRNA levels in tumors xenografted with human MV411 cells, achieving a fold change of 0.2. Additionally, FT001 achieves complete tumor growth inhibition (TGI) at 100.0% when administered at 12.5 mg/kg twice daily for 20 days in athymic Hsd:Foxn1nu mice xenografted with human MV411 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects against MV-4-11 and demonstrates significant MYC mRNA suppression both in vitro and in vivo.

化学信息

分子量	467.58
分子式	C₂₅H₂₉N₃O₄S
CAS No.	1778655-51-8
Smiles	C(=O)(N1C=2C(N(C(C)=O)[C@@H](C)C1)=CC=C(C2)C3=CC=C(C=C3)N4CCS(=O)(=O)CC4)C5CC5
密度	1.319 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (96.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1387 mL	10.6934 mL	21.3867 mL	106.9336 mL
5 mM	0.4277 mL	2.1387 mL	4.2773 mL	21.3867 mL
10 mM	0.2139 mL	1.0693 mL	2.1387 mL	10.6934 mL
20 mM	0.1069 mL	0.5347 mL	1.0693 mL	5.3467 mL
50 mM	0.0428 mL	0.2139 mL	0.4277 mL	2.1387 mL