Barlerin

Name: Barlerin
Brand: TargetMol
SKU: T5S1632
Price: 293 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.83%

货号 T5S1632Cas号 57420-46-9

别名 ND01, 8-O-乙酰山栀苷甲酯, 8-O-Acetylshanzhiside methyl ester

Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。

为众多的药物研发团队赋能，

让新药发现更简单！

Barlerin

一键复制产品信息

很棒

纯度: 99.83%

货号 T5S1632 别名 ND01, 8-O-乙酰山栀苷甲酯, 8-O-Acetylshanzhiside methyl esterCas号 57420-46-9

Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。

规格	价格	库存
1 mg	¥ 293	现货
2 mg	¥ 425	现货
5 mg	¥ 659	现货
10 mg	¥ 956	现货
25 mg	¥ 2,160	现货
50 mg	¥ 2,790	现货
100 mg	¥ 4,150	待询
1 mL x 10 mM (in DMSO)	¥ 728	现货

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

Barlerin 相关产品

产品介绍

生物活性

产品描述

Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.

别名

ND01, 8-O-乙酰山栀苷甲酯, 8-O-Acetylshanzhiside methyl ester

化学信息

分子量	448.42
分子式	C₁₉H₂₈O₁₂
CAS No.	57420-46-9
Smiles	COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1[C@H](O)C[C@]2(C)OC(C)=O
密度	1.52 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 82 mg/mL (182.86 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.36 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2301 mL	11.1503 mL	22.3005 mL	111.5026 mL
5 mM	0.4460 mL	2.2301 mL	4.4601 mL	22.3005 mL
10 mM	0.2230 mL	1.1150 mL	2.2301 mL	11.1503 mL
20 mM	0.1115 mL	0.5575 mL	1.1150 mL	5.5751 mL
50 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2301 mL
100 mM	0.0223 mL	0.1115 mL	0.2230 mL	1.1150 mL