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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Thioridazine hydrochloride

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纯度: 99.957%

货号 T0365Cas号 130-61-0

别名 盐酸硫利达嗪, Mellaril, Aldazine

Thioridazine hydrochloride (Mellaril) 是一种多巴胺受体D2家族蛋白的拮抗剂，有抗精神病和抗焦虑活性。它也是一种PI3K-Akt-mTOR 信号通路的抑制剂，具有抗血管生成作用。它在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用，对靶向癌症干细胞具有特异性。

Thioridazine hydrochloride
其他形式的 “Thioridazine hydrochloride”:
Thioridazine-d3 HCl
Thioridazine

Thioridazine hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.957%

货号 T0365 别名 盐酸硫利达嗪, Mellaril, AldazineCas号 130-61-0

Thioridazine hydrochloride (Mellaril) 是一种多巴胺受体D2家族蛋白的拮抗剂，有抗精神病和抗焦虑活性。它也是一种PI3K-Akt-mTOR 信号通路的抑制剂，具有抗血管生成作用。它在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用，对靶向癌症干细胞具有特异性。

规格价格库存数量
50 mg
¥ 298
现货
100 mg
¥ 418
现货
500 mg
¥ 671
现货
1 mL x 10 mM (in DMSO)
¥ 460
现货
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产品介绍

Thioridazine hydrochloride AI Summary
Thioridazine hydrochloride exhibits a broad spectrum of bioactivities across various biological targets and processes. It demonstrates significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 3981.07 nM to 12589.25 nM observed through a SYBR green assay after 72 hours of treatment. In addition to its antimalarial effects, Thioridazine hydrochloride shows potency in inhibiting menin-MLL interaction in MLL-related leukemias, Lamin A splicing, Jumonji Domain Containing 2E (JMJD2E), and other targets such as Tyrosyl-DNA Phosphodiesterase (TDP1) and Human Colon Tumor Cells growth. It also modulates miRNAs and affects lipid storage and Tau fibril formation. Moreover, Thioridazine hydrochloride displays high inhibitory effects on sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 95.52% and 81.91%, respectively, at a concentration of 10 μM, indicating potential interaction with OATP transporters. From an antiviral perspective, Thioridazine hydrochloride shows mild activity against SARS-CoV-2 with slight inhibition of cytotoxicity in Caco-2 and VERO-6 cells induced by the virus, and a 13.3% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Nonetheless, it exhibits low effectiveness in SARS-CoV-2 infected Vero E6 cells, with an inhibition index of -0.1314. Additionally, it demonstrates minimal antifungal activity against Candida albicans and Cryptococcus neoformans and limited antibacterial activity against several bacterial strains. Interestingly, Thioridazine hydrochloride also demonstrates antipsychotic activity in squirrel monkeys, indicated by its capability to inhibit conditioned avoidance response (ED50=0.97 mg/kg), suggesting potential applications in psychiatric conditions..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
别名盐酸硫利达嗪, Mellaril, Aldazine
化学信息
分子量407.04
分子式C21H27ClN2S2
CAS No.130-61-0
SmilesCl.CSc1cc2c(Sc3ccccc3N2CCC2CCCCN2C)cc1
密度1.1227 g/cm3 (Estimated)
颜色White
物理性状Solid
储存&溶解度
存储store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 55 mg/mL (135.12 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.91 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.4568 mL12.2838 mL24.5676 mL122.8381 mL
5 mM0.4914 mL2.4568 mL4.9135 mL24.5676 mL
10 mM0.2457 mL1.2284 mL2.4568 mL12.2838 mL
20 mM0.1228 mL0.6142 mL1.2284 mL6.1419 mL
50 mM0.0491 mL0.2457 mL0.4914 mL2.4568 mL
100 mM0.0246 mL0.1228 mL0.2457 mL1.2284 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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