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Fipexide

Name: Fipexide
Brand: TargetMol
SKU: T0322
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.95%

货号 T0322Cas号 34161-24-5

别名 非哌西特

Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。

Fipexide

一键复制产品信息

很棒

纯度: 99.95%

货号 T0322 别名 非哌西特Cas号 34161-24-5

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 236	现货
100 mg	¥ 425	现货
200 mg	¥ 730	现货
1 mL x 10 mM (in DMSO)	¥ 385	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.95%

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资源下载:

COA HPLC HNMR LCMS 产品操作手册

产品介绍

Fipexide AI Summary

Fipexide exhibits a wide range of bioactivities, including significant inhibition of acid sphingomyelinase (ASM) in human H4 cells, displaying an activity level of 121.3% at a concentration of 10 µM. This compound also shows potency across various biological assays, modulating Lamin A splicing, inhibiting mitochondrial division, and acting as both an agonist and antagonist in hypoxia response signaling pathways. It affects multiple Cytochrome P450 enzymes, showing interactions with enzymes like CYP2C19, CYP2D6, and CYP3A4, as well as human Hep3B cells where it induces cytotoxicity via these enzymes. In antiviral research, Fipexide has been observed to inhibit SARS-CoV-2-induced cytotoxicity of VERO-6 cells, albeit with a relatively weak IC50 value of greater than 20,000 nM. Additionally, it shows negligible inhibition of human HDAC6 enzyme activity. In terms of receptor interactions, Fipexide binds various receptors, including DRD1, SLC6A3, SLC6A2, SLC6A4, ADRA2A, OPRM1, DRD3, CHRM2, HTR1A, TBXA2R, ADORA3, HRH3, GABRA1, AR, and PGR. It also demonstrates antagonist activity at TBXA2R and CHRM1, and influences channels and enzymes such as KCNH2, ABCB11, MAOA, F2, KDR, PDE3A, SCN5A, PTGS1, and PDE4A with varying potency levels. Regarding safety, Fipexide presents moderate to severe liver toxicity. Clinical-chemistry results reveal significant elevations in ALT and AST levels, and it triggers acute forms of liver toxicity such as cytolytic hepatitis, though it appears less active in causing chronic liver diseases or tumors. It scores highly on Drug Induced Liver Injury (DILI) prediction systems and exhibits a liver toxicity severity index of 8.0. Overall, Fipexide showcases diverse pharmacological interactions and significant bioactivities, yet its therapeutic potential is offset by notable hepatotoxic risks..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever.
别名	非哌西特

化学信息

分子量	388.84
分子式	C₂₀H₂₁ClN₂O₄
CAS No.	34161-24-5
Smiles	Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1
密度	1.342g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (141.45 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5718 mL	12.8588 mL	25.7175 mL	128.5876 mL
5 mM	0.5144 mL	2.5718 mL	5.1435 mL	25.7175 mL
10 mM	0.2572 mL	1.2859 mL	2.5718 mL	12.8588 mL
20 mM	0.1286 mL	0.6429 mL	1.2859 mL	6.4294 mL
50 mM	0.0514 mL	0.2572 mL	0.5144 mL	2.5718 mL
100 mM	0.0257 mL	0.1286 mL	0.2572 mL	1.2859 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Fipexide

Fipexide

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Fipexide

Fipexide

Fipexide 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词