购物车
您的购物车当前为空
1-Aminocyclobutanecarboxylic acid
一键复制产品信息
很棒纯度: 99.94%
货号 T22542Cas号 22264-50-2
别名 ACBC, 1-氨基环丁烷羧酸
1-Aminocyclobutanecarboxylic acid (ACBC) 是一种NMDA 受体部分激动剂，作用于 NR1 甘氨酸位点。
为众多的药物研发团队赋能，
让新药发现更简单！
1-Aminocyclobutanecarboxylic acid
一键复制产品信息 很棒纯度: 99.94%
货号 T22542 别名 ACBC, 1-氨基环丁烷羧酸Cas号 22264-50-2
1-Aminocyclobutanecarboxylic acid (ACBC) 是一种NMDA 受体部分激动剂，作用于 NR1 甘氨酸位点。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 112 | 现货 | |
| 5 mg | ¥ 169 | 现货 | |
| 10 mg | ¥ 239 | 现货 | |
| 25 mg | ¥ 442 | 现货 | |
| 50 mg | ¥ 658 | 现货 | |
| 100 mg | ¥ 993 | 现货 | |
| 500 mg | ¥ 2,490 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
1-Aminocyclobutanecarboxylic acid AI Summary
1-Aminocyclobutanecarboxylic acid exhibits multi-faceted bioactivity across various assays. It shows in vitro inhibition of glycine at the NMDA receptor with an IC50 of 19,000 nM, and specifically in oocytes with an IC50 of 18,500 nM. In rat brain cortex membranes, it acts as a partial agonist at the glycine site of the NMDA receptor, potentiating [3H]Mk-801 binding by 53.0% relative to glycine in the presence of 5,7-dichlorokynurenic acid, and displaces [3H]glycine with a Ki value of 15,848.93 nM.
Beyond its effects on NMDA receptors, 1-Aminocyclobutanecarboxylic acid is notable for its inhibitory actions on several bio-targets: it inhibits the Menin-MLL interaction pivotal in MLL-related leukemias with a potency of 39,810.7 nM, Tau fibril formation and Thioflavin T binding at 12,589.3 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 79,432.8 nM, and Anthrax lethal toxin internalization at 12,589.3 nM. It also displays activity in the Cytochrome p450-cyp1a2 panel assay with an AC50 of 39,810.72 nM.
Additionally, 1-Aminocyclobutanecarboxylic acid significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, showing 95.93% and 131.14% inhibition respectively at a 10 µM substrate-inhibitor concentration, indicating potent effects on these transporters. Lastly, it inhibits ASCT2-mediated [3H]-D-serine uptake in rat hippocampal astrocytes at 1 mM concentration, reducing uptake by at least 25.0% within 5 minutes..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | 1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1]. |
| 别名 | ACBC, 1-氨基环丁烷羧酸 |
| 分子量 | 115.13 |
| 分子式 | C5H9NO2 |
| CAS No. | 22264-50-2 |
| Smiles | NC1(CCC1)C(O)=O |
| 密度 | 1.541g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | H2O: 25 mg/mL (217.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O
| ||||||||||||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy 1-Aminocyclobutanecarboxylic acid | purchase 1-Aminocyclobutanecarboxylic acid | 1-Aminocyclobutanecarboxylic acid cost | order 1-Aminocyclobutanecarboxylic acid | 1-Aminocyclobutanecarboxylic acid chemical structure | 1-Aminocyclobutanecarboxylic acid formula | 1-Aminocyclobutanecarboxylic acid molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441