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Olprinone

Name: Olprinone
Brand: TargetMol
SKU: T5033
Price: 141 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.68%

货号 T5033Cas号 106730-54-5

别名 奥普力农, Loprinone

Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。

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Olprinone

一键复制产品信息

很棒

纯度: 99.68%

货号 T5033 别名 奥普力农, LoprinoneCas号 106730-54-5

规格	价格	库存
1 mg	¥ 141	现货
5 mg	¥ 313	现货
10 mg	¥ 438	现货
25 mg	¥ 756	现货
50 mg	¥ 987	现货
100 mg	¥ 1,450	现货
200 mg	¥ 2,150	现货
1 mL x 10 mM (in DMSO)	¥ 311	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.68%

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

Olprinone AI Summary

Olprinone exhibits a diverse range of bioactivities, being particularly notable for its antiviral and enzyme inhibitory properties. It acts as a potentiator of the human D1 dopamine receptor with a potency of 3264.1 nM and shows significant inhibition against Histone Lysine Methyltransferase G9a at 12589.3 nM. It demonstrates promising inhibitory activity against T. brucei phosphofructokinase with a potency of 756.9 nM and inhibits HP1-beta Chromodomain interactions at 5011.9 nM. In human embryonic kidney cells, Olprinone inhibits ELG1-dependent DNA repair with a potency of 18348.9 nM and exhibits dual inhibitory activity on ATXN expression with potencies of 8912.5 nM and 3162.3 nM. Furthermore, this compound inhibits the Regulator of G Protein Signaling 4 at 37685.8 nM and has demonstrated potent inhibition of Marburg virus entry into cells (446.7 nM) and Lassa virus (32.6 nM). Additionally, it shows activity against HBL1 and TMD8 cell lines with potencies of 13206.6 nM and 2956.6 nM respectively and inhibits Plasmodium falciparum proliferation at potencies ranging from 0.7 nM to 16774.4 nM. In an immunotoxin study, it shows sensitization effects with a potency of 7426.6 nM. Olprinone also possesses antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, though the activity is relatively low with a hit score of 0.1194. It exhibits selective inhibition of human HDAC6, reducing enzymatic activity by -26.79% with a commercial peptide substrate. While generally displaying high AC50 values (>30,000.0 nM) in binding affinity towards various human receptors and enzymes, it effectively inhibits human PDE3A (AC50 = 707.6 nM) and PDE4A (AC50 = 5185.5 nM) in cell-free assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB).
靶点活性	PDE3:0.35 μM (IC50), PDE2:100 μM (IC50), PDE1:150 μM (IC50), PDE4:14 μM (IC50)
别名	奥普力农, Loprinone

化学信息

分子量	250.26
分子式	C₁₄H₁₀N₄O
CAS No.	106730-54-5
Smiles	Cc1[nH]c(=O)c(cc1-c1ccc2nccn2c1)C#N
密度	1.34g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 2.51 mg/mL (10.03 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9958 mL	19.9792 mL	39.9584 mL	199.7922 mL
5 mM	0.7992 mL	3.9958 mL	7.9917 mL	39.9584 mL
10 mM	0.3996 mL	1.9979 mL	3.9958 mL	19.9792 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

vasodilative positive Phosphodiesterase (PDE)phosphodiesterase PDE3 Olprinone inotropic Inhibitor inhibit heart failure cytokine anti-inflammatory

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产品介绍

计算器

体内实验配液计算器

剂量转换

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