Pyrazoloadenine

Name: Pyrazoloadenine
Brand: TargetMol
SKU: T9366
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.02%

货号 T9366Cas号 2380-63-4

别名 4-Aminopyrazolo[3,4-d]pyrimidine

Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) 是人黄嘌呤氧化酶的抑制剂。

Pyrazoloadenine

一键复制产品信息

很棒

纯度: 99.02%

货号 T9366 别名 4-Aminopyrazolo[3,4-d]pyrimidineCas号 2380-63-4

Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) 是人黄嘌呤氧化酶的抑制剂。

规格	价格	库存	数量
1 g	¥ 128	现货
1 mL x 10 mM (in DMSO)	¥ 117	现货

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产品介绍

Pyrazoloadenine AI Summary

Pyrazoloadenine is a multifaceted bioactive molecule exhibiting diverse inhibitory activities. It demonstrates inhibitory activity against human phosphatidylinositol 4-kinase at the ATP binding site with an IC50 value of 144900.0 nM and a binding affinity (Ki value) of 99900.0 nM. Additionally, it functions as an inhibitor of human xanthine oxidase, with an IC50 value of 30260.0 nM and 49.8% inhibition efficacy at a 30 µM concentration. Pyrazoloadenine also shows pronounced antitrypanosomal and antileishmanial activities, effectively inhibiting nifurtimox-sensitive Trypanosoma cruzi in human cells with an IC50 value of 570.0 nM and exhibiting antileishmanial activity against Leishmania infantum in mouse peritoneal macrophages with an IC50 value of 180.0 nM, accompanied by high selectivity indices for both activities. Moreover, the compound inhibits the LRRK2 G2019S mutant kinase with an IC50 value of 26630.0 nM and a Ki value of 11312.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.
别名	4-Aminopyrazolo[3,4-d]pyrimidine

化学信息

分子量	135.13
分子式	C₅H₅N₅
CAS No.	2380-63-4
Smiles	NC1=NC=NC2=NNC=C12
密度	1.612g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10.83 mg/mL (80.15 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.4003 mL	37.0014 mL	74.0028 mL	370.0141 mL
5 mM	1.4801 mL	7.4003 mL	14.8006 mL	74.0028 mL
10 mM	0.7400 mL	3.7001 mL	7.4003 mL	37.0014 mL
20 mM	0.3700 mL	1.8501 mL	3.7001 mL	18.5007 mL
50 mM	0.1480 mL	0.7400 mL	1.4801 mL	7.4003 mL