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3'-Deoxy-3'-fluoroguanosine

Name: 3'-Deoxy-3'-fluoroguanosine
Brand: TargetMol
SKU: TNU0091
Price: 138 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.63%

货号 TNU0091Cas号 123402-21-1

别名 3'-氟-3'-脱氧鸟苷

3'-Deoxy-3'-fluoroguanosine 是一种核苷磷酸化酶抑制剂，通过结合复制子抑制RNA的复制。3'-Deoxy-3'-fluoroguanosine 可用于治疗病毒性肝炎、癌症和其他疾病。

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3'-Deoxy-3'-fluoroguanosine

一键复制产品信息

很棒

纯度: 98.63%

货号 TNU0091 别名 3'-氟-3'-脱氧鸟苷Cas号 123402-21-1

3'-Deoxy-3'-fluoroguanosine 是一种核苷磷酸化酶抑制剂，通过结合复制子抑制RNA的复制。3'-Deoxy-3'-fluoroguanosine 可用于治疗病毒性肝炎、癌症和其他疾病。

规格	价格	库存
2 mg	¥ 138	现货
5 mg	¥ 223	现货
10 mg	¥ 335	现货
25 mg	¥ 592	现货
50 mg	¥ 882	现货
100 mg	¥ 1,180	现货
200 mg	¥ 1,750	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 98.63%

颜色: 黄色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

3'-Deoxy-3'-fluoroguanosine AI Summary

3'-Deoxy-3'-fluoroguanosine displays a range of bioactivities across various biological systems. It alters cell morphology in numerous cell types at different concentrations and exerts antiviral activity against several viruses, demonstrated by varying minimum inhibitory concentrations (MICs) in different cell types. This compound particularly inhibits HCV NS5B-mediated RNA synthesis with an IC50 of 1800.0 nM and HCV RNA replication with an EC50 greater than 50000.0 nM. Additionally, it shows notable inhibitory effects on cancer cell lines, marked by varying half-maximal inhibitory concentrations (IC50s). 3'-Deoxy-3'-fluoroguanosine also has specific antiparasitic activities, including: - Antitrypanosomal activity against Trypanosoma brucei brucei with an EC50 of 42,000.0 nM. - Antileishmanial activity against Leishmania infantum with an EC50 of 46,900.0 nM. - Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 in human MRC5 cells with an EC50 of 34,600.0 nM. Moreover, it exhibits cytotoxicity against mouse primary macrophage cells, with an EC50 greater than 64,000.0 nM, suggesting a selectivity index that favors its antileishmanial and antitrypanosomal activities over cytotoxic effects on macrophage and human MRC5 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons. 3 '-Deoxy-3' -fluoroguanosine is used to treat viral hepatitis, cancer and other diseases.
别名	3'-氟-3'-脱氧鸟苷

化学信息

分子量	285.23
分子式	C₁₀H₁₂FN₅O₄
CAS No.	123402-21-1
Smiles	Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](F)[C@H]1O

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 13.75 mg/mL (48.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.01 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5059 mL	17.5297 mL	35.0594 mL	175.2971 mL
5 mM	0.7012 mL	3.5059 mL	7.0119 mL	35.0594 mL
10 mM	0.3506 mL	1.7530 mL	3.5059 mL	17.5297 mL
20 mM	0.1753 mL	0.8765 mL	1.7530 mL	8.7649 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。