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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Nortriptyline hydrochloride

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Rating icon 很棒

纯度: 99.85%

货号 T1327Cas号 894-71-3

别名 盐酸去甲替林, 去甲替林, EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HCl

Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。

Nortriptyline hydrochloride
其他形式的 “Nortriptyline hydrochloride”:
Nortriptyline-d3 HCl
Nortriptyline

Nortriptyline hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.85%

货号 T1327 别名 盐酸去甲替林, 去甲替林, EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HClCas号 894-71-3

Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。

规格价格库存数量
5 mg
¥ 129
现货
10 mg
¥ 173
现货
25 mg
¥ 269
现货
50 mg
¥ 373
现货
100 mg
¥ 538
现货
200 mg
¥ 788
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500 mg
¥ 1,320
现货
1 g
¥ 1,960
现货
1 mL x 10 mM (in DMSO)
¥ 145
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产品介绍

Nortriptyline hydrochloride AI Summary
Nortriptyline hydrochloride displays a broad spectrum of bioactivities across various cellular and molecular assays. It demonstrates antiplasmodial activity against different strains of Plasmodium falciparum with IC50 values ranging from 2238.7 nM to 12589.25 nM, suggesting potential in malaria treatment. Additionally, it acts as a modulator of Lamin A splicing, induces erasure of genomic imprints, and enhances SMN2 splice variant expression at varying potencies. The compound also exhibits antiviral properties, showing inhibitory effects against virus entry for Lassa and Marburg viruses and SARS-CoV-2. Specifically, it inhibits SARS-CoV-2-induced cytotoxicity in Vero E6 cells and Caco-2 cells, and inhibits the SARS-CoV-2 3CL-Pro protease by 31.79% at 20 µM. Furthermore, Nortriptyline hydrochloride shows antifungal activity against Candida albicans and Cryptococcus neoformans, albeit with low percentages of inhibition. Its antibacterial activity was noted against multiple strains including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, demonstrating varying levels of efficacy. In the context of cancer, Nortriptyline hydrochloride inhibits the growth of various human tumor cell lines with GI50 values from 6137.62 nM to 36982.82 nM. It also disrupts the Norepinephrine transporter (NET) with a potent IC50 value of 40.0 nM. Overall, Nortriptyline hydrochloride is a multi-target compound with activities spanning antimalarial, antiviral, antifungal, antibacterial, anticancer, and transporter inhibition properties, indicating its significant potential for therapeutic development..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
别名盐酸去甲替林, 去甲替林, EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HCl
化学信息
分子量299.84
分子式C19H22ClN
CAS No.894-71-3
SmilesCl.CNCC\C=C1\c2ccccc2CCc2ccccc12
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: 54 mg/mL (180.1 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.67 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol
1mg5mg10mg50mg
1 mM3.3351 mL16.6756 mL33.3511 mL166.7556 mL
5 mM0.6670 mL3.3351 mL6.6702 mL33.3511 mL
10 mM0.3335 mL1.6676 mL3.3351 mL16.6756 mL
20 mM0.1668 mL0.8338 mL1.6676 mL8.3378 mL
50 mM0.0667 mL0.3335 mL0.6670 mL3.3351 mL
100 mM0.0334 mL0.1668 mL0.3335 mL1.6676 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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