Pipemidic acid

Name: Pipemidic acid
Brand: TargetMol
SKU: T0396
Rating: 4.5 (1 reviews)

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纯度: 99.65%

货号 T0396Cas号 51940-44-4

别名 吡哌酸, Acido pipemidico

Pipemidic acid (Acido pipemidico) 是一种新型抗菌剂，对革兰氏阴性菌和某些革兰氏阳性细菌具有活性，可研究肠道、泌尿和胆道感染。

Pipemidic acid

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还可以

纯度: 99.65%

货号 T0396 别名 吡哌酸, Acido pipemidicoCas号 51940-44-4

Pipemidic acid (Acido pipemidico) 是一种新型抗菌剂，对革兰氏阴性菌和某些革兰氏阳性细菌具有活性，可研究肠道、泌尿和胆道感染。

规格	价格	库存
50 mg	¥ 140	待询
100 mg	¥ 197	待询
500 mg	¥ 415	待询

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产品介绍

Pipemidic acid AI Summary

Pipemidic acid exhibits a range of bioactivities, including significant antibacterial, antiviral, and antimalarial effects. It shows potent in vitro antibacterial activity against various clinical isolates, with MIC values ranging from 0.39 to 31.2 µg/mL against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Bacillus subtilis, Salmonella typhimurium, and Micrococcus luteus. However, it has limited efficacy against certain strains of Staphylococcus aureus and Pseudomonas aeruginosa with MIC values greater than 16.0 µg/mL and 25.0 µg/mL, respectively. Additionally, Pipemidic acid demonstrates moderate antiviral activity against SARS-CoV-2, inhibiting viral cytotoxicity in cell assays with an IC50 value above 20,000 nM. The compound also shows moderate antimalarial activity against Plasmodium parasites, with IC50 values of 10.5 µg/mL against the blood stage of chloroquine-sensitive Plasmodium falciparum NF54-R strain and above 100 µg/mL against the hepatic stage of Plasmodium yoelii yoelii 265 BY. Furthermore, it is involved in inhibiting DNA gyrase, human HDAC6 enzyme, and the SARS-CoV-2 3CL-Pro protease. Pipemidic acid is associated with hepatotoxicity under specific conditions and has influenced bioactivities in assays related to USP1/UAF1 inhibitors and PhoP region inhibition in Salmonella. The compound’s lipophilicity and its performance in assays related to the inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells have also been noted..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa.
别名	吡哌酸, Acido pipemidico

化学信息

分子量	303.32
分子式	C₁₄H₁₇N₅O₃
CAS No.	51940-44-4
Smiles	C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CN=C(N2)N3CCNCC3
密度	1.38g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.