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Thiophanate-Methyl

Name: Thiophanate-Methyl
Brand: TargetMol
SKU: T6944
Price: 115 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.58%

货号 T6944Cas号 23564-05-8

别名 甲基硫菌灵

Thiophanate-Methyl 是一种甲基苯并咪唑氨基甲酸酯杀菌剂。

为众多的药物研发团队赋能，

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Thiophanate-Methyl

一键复制产品信息

很棒

纯度: 99.58%

货号 T6944 别名 甲基硫菌灵Cas号 23564-05-8

Thiophanate-Methyl 是一种甲基苯并咪唑氨基甲酸酯杀菌剂。

规格	价格	库存
50 mg	¥ 115	现货
100 mg	¥ 153	现货
500 mg	¥ 328	现货
1 g	¥ 538	现货
1 mL x 10 mM (in DMSO)	¥ 363	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.58%

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COA HNMR HPLC 产品操作手册

产品介绍

Thiophanate-Methyl AI Summary

Thiophanate-Methyl exhibits a broad range of bioactivities, including notable antifungal, antiviral, and enzyme-inhibitory properties. It demonstrates substantial antifungal activity against a variety of pathogens, such as Colletotrichum fragariae, Fusarium oxysporum, Pestalotiopsis microspora, and Thanatephorus cucumeris, with significant inhibitory effects on mycelial growth, conidium germination, and disease control in plants. Specifically, it inhibits mycelial growth with Minimum Inhibitory Concentration (MIC) values of 4000.0 ppm for Cochliobolus pallescens, Fusarium oxysporum, and Glomerella tucumanensis, and shows an EC50 as low as 10.84 ug/mL against Rhizoctonia solani AG-1 IA and 1.03 ug/mL against Botryotinia fuckeliana. In addition to its antifungal properties, Thiophanate-Methyl has antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 uM and demonstrating -3.43% and 0.14% inhibition respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 11.73% at 20 µM. Enzyme inhibition studies reveal that Thiophanate-Methyl is a potent inhibitor of various enzymes including HSD17B4, ALDH1A1, and Bacillus subtilis Sfp PPTase, with potencies ranging from 316.2 nM to 50118.7 nM. It also inhibits human FAAH at 1 uM with an 8.37% inhibition rate, and HDAC6 enzyme with mixed results depending on the substrate used. Overall, Thiophanate-Methyl displays a diverse spectrum of biological activities, making it a promising candidate for further research in antifungal therapy, antiviral treatment, and enzyme inhibition applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thiophanate-Methyl (TM), a methyl benzimidazole carbamate (MBC) fungicide,
别名	甲基硫菌灵

化学信息

分子量	342.39
分子式	C₁₂H₁₄N₄O₄S₂
CAS No.	23564-05-8
Smiles	COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC
密度	1.4542 g/cm3 (Estimated)

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 83.33 mg/mL (243.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.6 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9206 mL	14.6032 mL	29.2065 mL	146.0323 mL
5 mM	0.5841 mL	2.9206 mL	5.8413 mL	29.2065 mL
10 mM	0.2921 mL	1.4603 mL	2.9206 mL	14.6032 mL
20 mM	0.1460 mL	0.7302 mL	1.4603 mL	7.3016 mL
50 mM	0.0584 mL	0.2921 mL	0.5841 mL	2.9206 mL
100 mM	0.0292 mL	0.1460 mL	0.2921 mL	1.4603 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Thiophanate-Methyl ThiophanateMethyl Thiophanate Methyl Inhibitor inhibit Fungal Antifungal

Thiophanate-Methyl

Thiophanate-Methyl