规格

价格

库存

数量

1 mg

¥ 293

现货

5 mg

¥ 687

现货

10 mg

¥ 1,090

现货

25 mg

¥ 1,920

现货

50 mg

¥ 2,920

现货

1 mL x 10 mM (in DMSO)

¥ 496

现货

生物活性

产品描述	AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
靶点活性	ATM:0.31 μM (in cell), ATM:6.2 nM
体外活性	AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1].
体内活性	AZ32 has enhanced BBB penetration that is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours[1].

化学信息

分子量	328.37
分子式	C₂₀H₁₆N₄O
CAS No.	2288709-96-4
Smiles	CNC(=O)c1ccc(cc1)-c1cnc2cnc(cn12)-c1ccccc1
密度	1.25 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 55 mg/mL (167.49 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.09 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0453 mL	15.2267 mL	30.4535 mL	152.2673 mL
5 mM	0.6091 mL	3.0453 mL	6.0907 mL	30.4535 mL
10 mM	0.3045 mL	1.5227 mL	3.0453 mL	15.2267 mL
20 mM	0.1523 mL	0.7613 mL	1.5227 mL	7.6134 mL
50 mM	0.0609 mL	0.3045 mL	0.6091 mL	3.0453 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5227 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

AZ32

AZ32

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

AZ32

AZ32

AZ32 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词