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Cloxiquine

Name: Cloxiquine
Brand: TargetMol
SKU: T0509
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T0509Cas号 130-16-5

别名 氯羟喹, Dermofungin, Dermofongin, 5-氯-8-羟基喹啉, 5-Chloro-8-quinolinol

Cloxiquine (Dermofongin) 具有抗菌，抗真菌和抗阿米巴虫的作用。它还可通过激活 PPARγ抑制黑素瘤细胞的生长和转移。它可研究结核病和皮肤病。

Cloxiquine

一键复制产品信息

很棒

纯度: 99.87%

货号 T0509 别名 氯羟喹, Dermofungin, Dermofongin, 5-氯-8-羟基喹啉, 5-Chloro-8-quinolinolCas号 130-16-5

Cloxiquine (Dermofongin) 具有抗菌，抗真菌和抗阿米巴虫的作用。它还可通过激活 PPARγ抑制黑素瘤细胞的生长和转移。它可研究结核病和皮肤病。

规格	价格	库存
500 mg	¥ 99	现货
5 g	¥ 163	现货
10 g	¥ 226	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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纯度: 99.82%

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COA LCMS HNMR 产品操作手册

产品介绍

Cloxiquine AI Summary

Cloxiquine demonstrates notable bioactivity across a broad spectrum of targets, exhibiting potent antimycobacterial efficacy against multiple Mycobacterium tuberculosis strains, including drug-resistant varieties with a low MIC of 0.125 ug/mL. It is effective against pulmonary tuberculosis isolates, with MIC50 and MIC90 values of 0.125 ug/mL and 0.25 ug/mL, respectively. The compound displays moderating influence on Lamin A splicing, inhibition of Tau fibril formation, and various enzyme activities including significant inhibition of MMP enzymes and human integrase. At a concentration of 1 mM, it inhibits MMP2 (60.0%), MMP8 (73.0%), MMP1 (39.0%), and MMP3 (45.0%), but shows minimal inhibition of MMP9. Additionally, it doesn't affect mushroom tyrosinase. It exhibits moderate lipophilicity with a logP around 2.91-2.94, and pKa values indicating potential ionization variability in different environments, potentially impacting its solubility and bioavailability. Further, Cloxiquine inhibits human methionine aminopeptidase 2 with an IC50 of 1270.0 nM and 1A from Rickettsia prowazekii with IC50 of 900.0 nM. It also inhibits the protease activity of Clostridium botulinum with an IC50 of 1900.0 nM and displays significant inhibitory actions against the NDM-1 enzyme. Its activities extend to inhibition of BRD4 and COMT in rat liver, alongside moderate cytotoxicity against human cancer cell lines MES-SA and MES-SA/Dx5 with IC50 values between 5130.0 to 8320.0 nM. Cloxiquine also shows antiviral properties, particularly against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells, although with a relatively high IC50 value (> 20,000.0 nM). Moreover, it reveals inhibition of human HDAC6 and BSEP activities, signifying its broad-spectrum potential in various biological assays and therapeutic possibilities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
别名	氯羟喹, Dermofungin, Dermofongin, 5-氯-8-羟基喹啉, 5-Chloro-8-quinolinol

化学信息

分子量	179.6
分子式	C₉H₆ClNO
CAS No.	130-16-5
Smiles	ClC=1C2=C(C(O)=CC1)N=CC=C2
密度	1.412 g/cm3

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (306.24 mM), Sonication is recommended.

Ethanol: 33 mg/mL (183.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.14 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5679 mL	27.8396 mL	55.6793 mL	278.3964 mL
5 mM	1.1136 mL	5.5679 mL	11.1359 mL	55.6793 mL
10 mM	0.5568 mL	2.7840 mL	5.5679 mL	27.8396 mL
20 mM	0.2784 mL	1.3920 mL	2.7840 mL	13.9198 mL
50 mM	0.1114 mL	0.5568 mL	1.1136 mL	5.5679 mL
100 mM	0.0557 mL	0.2784 mL	0.5568 mL	2.7840 mL