Oxcarbazepine

Name: Oxcarbazepine
Brand: TargetMol
SKU: T0440
Price: 281 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.46%

货号 T0440Cas号 28721-07-5

别名 奥卡西平, GP 47680

Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。

Oxcarbazepine

一键复制产品信息

很棒

纯度: 98.46%

货号 T0440 别名 奥卡西平, GP 47680Cas号 28721-07-5

Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。

规格	价格	库存
5 mg	¥ 281	现货
10 mg	¥ 457	现货
50 mg	¥ 912	现货
100 mg	¥ 1,392	现货
200 mg	¥ 1,671	现货
500 mg	¥ 2,434	现货
1 mL x 10 mM (in DMSO)	¥ 498	现货

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产品介绍

Oxcarbazepine AI Summary

Oxcarbazepine exhibits anticonvulsant activity, demonstrating a 68.3% protection rate against MES-induced seizures in rats. It has a rapid onset of effect, with a Tmax of 0.08333 hr intraperitoneally and 2.0 hr via gastric tube. The compound’s ED50 values are 6.1 mg.kg-1 intraperitoneally and 10.0 mg.kg-1 via gastric tube. Toxicity measures include a TD50 of 40.1 mg.kg-1 in the rotarod test and greater than 1000.0 mg.kg-1 by gastric administration. It inhibits voltage-gated sodium channels in rat cortical synaptosomes with an IC50 of less than 161000.0 nM and shows dose-dependent inhibition of 22Na+ uptake. Additionally, Oxcarbazepine inhibits the human aquaporin 4 M23 isoform at 20 µM (33% inhibition). It has good solubility in 0.1 M phosphate buffer and water and exhibits broad bioactivity, including inhibition of various human targets, chronic active B-cell receptor signaling, and more. It also influences liver and kidney function markers and shows cytotoxicity against HepG2 cells with an IC50 of 19498.45 nM. Pharmacokinetically, Oxcarbazepine has a LogD7.4 of 1.28 and a LogP of 20.4. It has low oral bioavailability (F = 0.99%) and various AUC values depending on the assay. The compound shows significant bioactivity in modulating transport processes mediated by OATP1B1 and OATP1B3 and has antagonist activity at the P2X4 receptor, with an IC50 greater than 10,000.0 nM. Additionally, it demonstrates a half-life of 2.0 hours and shows inhibitory activity against multiple drug transporters like BSEP, MRP2, MRP3, and MRP4. Oxcarbazepine has minimal effectiveness against SARS-CoV-2 under tested conditions but shows antibacterial and antifungal activities. Lastly, it inhibits human HDAC6 with strong potency in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
靶点活性	Na+ channel:160 μM
别名	奥卡西平, GP 47680

化学信息

分子量	252.27
分子式	C₁₅H₁₂N₂O₂
CAS No.	28721-07-5
Smiles	C(N)(=O)N1C=2C(C(=O)CC=3C1=CC=CC3)=CC=CC2
密度	1.329g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 18 mg/mL (71.35 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9640 mL	19.8200 mL	39.6401 mL	198.2003 mL
5 mM	0.7928 mL	3.9640 mL	7.9280 mL	39.6401 mL
10 mM	0.3964 mL	1.9820 mL	3.9640 mL	19.8200 mL
20 mM	0.1982 mL	0.9910 mL	1.9820 mL	9.9100 mL
50 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9640 mL