Carboxin

Name: Carboxin
Brand: TargetMol
SKU: T5559
Price: 146 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.52%

货号 T5559Cas号 5234-68-4

别名 萎锈灵, Vitavax, Kisvax, Carboxine, Carbathiin

Carboxin (Kisvax)e 是一种内吸杀菌剂和种子保护剂。

Carboxin

一键复制产品信息

很棒

纯度: 99.52%

货号 T5559 别名 萎锈灵, Vitavax, Kisvax, Carboxine, CarbathiinCas号 5234-68-4

Carboxin (Kisvax)e 是一种内吸杀菌剂和种子保护剂。

规格	价格	库存
10 mg	¥ 146	现货
25 mg	¥ 213	现货
50 mg	¥ 295	现货
100 mg	¥ 418	现货

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产品介绍

Carboxin AI Summary

Carboxin exhibits a variety of bioactivities across different biological systems and organisms. It shows potency in modulating miRNAs, lipid storage in Drosophila cells, inhibiting the ERK signaling pathway, HADH2, and miR-21, as well as inhibiting Nrf2, histone lysine methyltransferase G9a, HP1-beta chromodomain interactions, peroxisome proliferator-activated receptor delta signaling, DNA re-replication in colon adenocarcinoma cells, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). The compound also activates the human pregnane X receptor (PXR) and antioxidant response element (ARE) signaling pathways and serves as an agonist for cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1), Aryl hydrocarbon Receptor (AhR) signaling pathway, and rat pregnane X receptor (rPXR) signaling pathway. Additionally, it has demonstrated delayed death inhibition of the malarial parasite and activity against firefly luciferase. Carboxin shows significant antiviral activity against SARS-CoV-2 with an IC50 value greater than 20000.0 nM, exhibiting moderate potency. It also possesses antifungal activity against Fusarium graminearum and Fusarium oxysporum, with growth inhibition of 56.3% and 23.6%, respectively, at 100 µg/ml. Its antifungal efficacy extends to controlling wheat leaf rust disease caused by Puccinia recondita with 100% efficacy at 50 µg/ml and 43.0% at 20 µg/ml, and fungicidal activity against Oculimacula yallundae with an EC50 value of 2.5 µg/ml. In terms of antiparasitic activity, Carboxin is effective against the Chagas Disease parasite Trypanosoma cruzi with an IC50 value of 22410.0 nM and an IC90 value of 57500.0 nM, showing no cytotoxicity against L-6 rat myoblasts up to 100000.0 nM. Additionally, it exhibits bioactivities related to resistance in sterol 14alpha-demethylation inhibitor-resistant strains of Oculimacula yallundae..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant.
别名	萎锈灵, Vitavax, Kisvax, Carboxine, Carbathiin

化学信息

分子量	235.30
分子式	C₁₂H₁₃NO₂S
CAS No.	5234-68-4
Smiles	CC1=C(SCCO1)C(=O)NC1=CC=CC=C1
密度	1.45

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 47 mg/mL (199.75 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.5 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2499 mL	21.2495 mL	42.4989 mL	212.4947 mL
5 mM	0.8500 mL	4.2499 mL	8.4998 mL	42.4989 mL
10 mM	0.4250 mL	2.1249 mL	4.2499 mL	21.2495 mL
20 mM	0.2125 mL	1.0625 mL	2.1249 mL	10.6247 mL
50 mM	0.0850 mL	0.4250 mL	0.8500 mL	4.2499 mL
100 mM	0.0425 mL	0.2125 mL	0.4250 mL	2.1249 mL