K-Ras-IN-1

Name: K-Ras-IN-1
Brand: TargetMol
SKU: T5469
Price: 187 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.72%

货号 T5469Cas号 84783-01-7

K-Ras-IN-1 是K-Ras 抑制剂。K-Ras-IN-1 能与 K-Ras (WT)、K-Ras (G12D)、K-Ras (G12V) 和 H-Ras 结合。它对胰腺癌、结肠癌和肺癌的具潜在的研究价值。

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K-Ras-IN-1

一键复制产品信息

很棒

纯度: 98.72%

货号 T5469Cas号 84783-01-7

K-Ras-IN-1 是K-Ras 抑制剂。K-Ras-IN-1 能与 K-Ras (WT)、K-Ras (G12D)、K-Ras (G12V) 和 H-Ras 结合。它对胰腺癌、结肠癌和肺癌的具潜在的研究价值。

规格	价格	库存
1 mg	¥ 187	现货
5 mg	¥ 449	现货
10 mg	¥ 721	现货
25 mg	¥ 1,330	现货
50 mg	¥ 2,080	现货
100 mg	¥ 2,880	现货
200 mg	¥ 3,890	现货
1 mL x 10 mM (in DMSO)	¥ 496	现货

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纯度: 98.72%

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COA HNMR LCMS 产品操作手册

产品介绍

K-Ras-IN-1 AI Summary

K-Ras-IN-1 exhibits a diverse range of bioactivities across various biological assays. It demonstrates potency in inhibiting lipid storage in Drosophila S3 cells and Bacillus subtilis Sfp phosphopantetheinyl transferase. Additionally, it shows inhibitory activity against AmpC Beta-Lactamase and inhibits ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells. K-Ras-IN-1 also acts as an inhibitor of the vitamin D receptor (VDR) and as a delayed death inhibitor of the malarial parasite plastid. It induces DNA re-replication in SW480 colon adenocarcinoma cells and inhibits the PLK1-PDB (polo-like kinase 1 - polo-box domain). Moreover, K-Ras-IN-1 shows a binding affinity to the Ras SOS1 binding site with an activity of 1.3 mM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	K-Ras-IN-1 is a K-Ras inhibitor.

化学信息

分子量	207.29
分子式	C₁₁H₁₃NOS
CAS No.	84783-01-7
Smiles	Oc1ccccc1C(=S)N1CCCC1
密度	no data available
颜色	White
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 28 mg/mL (135.08 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8242 mL	24.1208 mL	48.2416 mL	241.2080 mL
5 mM	0.9648 mL	4.8242 mL	9.6483 mL	48.2416 mL
10 mM	0.4824 mL	2.4121 mL	4.8242 mL	24.1208 mL
20 mM	0.2412 mL	1.2060 mL	2.4121 mL	12.0604 mL
50 mM	0.0965 mL	0.4824 mL	0.9648 mL	4.8242 mL
100 mM	0.0482 mL	0.2412 mL	0.4824 mL	2.4121 mL